Hippo信号通路(Hippo signaling pathway)是最先在果蝇里通过遗传筛选发现的一条经典信号通路,后续工作发现该信号通路在哺乳动物中同样高度保守。Hippo信号通路在调控组织生长、维持组织稳态(tissue homeostasis)以及再生修复等过程中均扮演重要角色。Hippo信号通路失调会导致多种疾病的发生,包括癌症。 美国德克萨斯大学西南医学...
Hippo signalling pathway controls cell proliferation and survival mainly by sensing the physical state of cells within a tissue through several mechanisms. Unlike other pathways, Hippo does not have dedicated extracellular ligand–receptor complexes. Instead, the upstream signaling of Hippo involves many ...
YAP基因所在的11q22染色体被报道在肝癌中存在局部扩增现象,但这仅是一个低频事件;另外,在肝癌样本中很少检测到Hippo信号通路关键成分的突变【2-3】。这表明在肝癌发生发展过程中,Hippo信号通路的失调可能受其他癌蛋白或蛋白质翻译后修饰等的...
近年来,基于抗体和细胞的靶向疗法方兴未艾,如果能鉴定出一种体现Hippo通路活性的细胞表面标志物,将为靶向Hippo通路的肿瘤治疗带来全新可能性。 2022年8月30日,复旦大学生物医学研究院余发星课题组在Cell Reports杂志以长文形式发表了题为Transmem...
The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep, 2014, 15(6): 642-656. 9. Zhao B, Wei X, Li W, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev, 2007, 21(21): 2747-...
Hippo signaling: growth control and beyond The Hippo Signaling Pathway in Development and Cancer The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. ...
The research progress of Hippo-YAP signaling pathway and various diseases is reviewed in this paper.%Hippo 信号通路是一个能够调控细胞分裂增殖分化和凋亡的信号通路,YAP 是该通路的一个效应因子,有着启动 Hippo 通路基因转录翻译的能力。实验证实 Hippo 信号通路和 YAP 对多种疾病都具有重要影响,特别是癌症和...
The MAPK Signaling Pathway 01:54 The MAP Kinase (MAPK) signalling pathway 05:06 Smad Pathway 05:07 Apoptotic Pathways 02:05 TGF Beta Signalling Pathway 06:01 Hippo Signaling Regulates : miRNA Biogenesis to Cancer 05:18 Hippo Pathway: YAPing Hippo Forecasts new targets in lung cancer 02:34 Hi...
[Key words] Cardiovascular diseases; Hippo-YAP signaling pathway; Myocardial infarction; Myocardial fibrosis; Myocardial hypertrophy; Arrhythmia; Atherosclerosis Hippo 通路相关基因是在对果蝇进行遗传基因 筛查过程中被发现,并确定其与生长控制相关 [1]. 随后,在对脊椎动物的研究中,研究者发现 Hippo 通 路具有...