Hippo信号通路(Hippo signaling pathway)是最先在果蝇里通过遗传筛选发现的一条经典信号通路,后续工作发现该信号通路在哺乳动物中同样高度保守。Hippo信号通路在调控组织生长、维持组织稳态(tissue homeostasis)以及再生修复等过程中均扮演重要角色。Hippo信号通路失调会导致多种疾病的发生,包括癌症。 美国德克萨斯大学西南医学...
Hippo信号通路通过调控YAP活性，在哺乳动物体内维持细胞增殖与组织生长的平衡，是细胞周期调控和肿瘤抑制的关键。
Hippo signaling pathway 哺乳动物中的 Hippo/yes-associated protein (YAP)信号通路 首先,Hippo 信号通路最早是在果蝇上发现,是果蝇组织生长的关键调节因子,当Hippo信号通路没有被激活的时候,YAP进入细胞核结合相关的转录因子,调控细胞增殖,控制动物组织的生长。 当Hippo信号通路激活后,就会通过磷酸化MST1/2,激活MST1/...
Hippo signaling pathway is an evolutionarily conserved pathway that responds to various environmental cues and controls organ size, cell proliferation, death, and self-renewal capacity. From:Genes & Diseases,2021 About this page Set alert Also in subject area: ...
The hippo signaling pathway is a highly conserved evolutionary signaling pathway that plays an important role in regulating cell proliferation, organ size, tissue development, and regeneration. Increasing evidences consider that the hippo signaling pathw
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Coordination between cell proliferation and cell death is essential to maintain homeostasis in multicellular organisms. In Drosophila, these two processes ......
Fig. 1. Hippo signaling pathway components. α-catenin is cleaved by caspase-3, thereby facilitating the activation and nuclear translocation of YAP (Yosefzon, Soteriou, et al., 2018). Amot can activate the Hippo pathway by binding to and activating LATS at the adherens junctions of cells, ...
Zhang H, Han L, Du D, Creighton CJ, Mills GB, Camargo F, Liang H. Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.Cell Rep.2018 Oct 30;25(5):1304-1317.e5. doi: 10.1016/j.celrep....
[2]ZHENG Y, PAN D. The Hippo Signaling Pathway in Development and Disease [J].Dev Cell, 2019, 50(3): 264-82. [3]DEY A, VARELAS X, GUAN K L. Targeting the Hippo pathway in cancer, fibrosis, wound healing and ...