‘hinge’ region and the N-terminal hormone-binding region form an integral domain (Fig. 6). The signal specificity sequence adds two additional β-strands (LRRs 11 and 12) and a helix to the first 10LRRsrevealed in the Fan-Hendrickson structure. The activation-sensitive residue S273 is ...
REPETITIVE HINGE REGION SEQUENCES IN A γ3 HEAVY CHAIN DISEASE PROTEIN-ISOLATION OF AN 11,000 DALTON FRAGMENTdoi:10.1016/B978-0-12-651050-8.50020-XB.F. FrangioneJ.B. AdlersbergE.C. FranklinMolecular Approaches to Immunology
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides" setting - the physical position of something; "he changed the setting on the thermostat" juxtaposition - a side-by-side position lie - position or manner ...
Through a comparative and comprehensive analysis of fault mechanism solutions in the Nile Delta region and its surroundings, we have concluded that the fault structures in the Hinge Zone and Cairo-Suez Shear Zone exhibit similarities. This finding provides evidence that the geodynamic processes and ...
and a vapor chamber extending from the first portion to the second portion across the hinge region, the vapor chamber comprising a first layer comprising titanium, a second layer comprising titanium joined to the first layer to form the vapor chamber, a working fluid within the vapor chamber, ...
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides" setting - the physical position of something; "he changed the setting on the thermostat" juxtaposition - a side-by-side position lie - position or manner ...
Relating features of protein sequences to structural hinges is important for identifying domain boundaries, understanding structure-function relationships, and designing flexibility into proteins. Efforts in this field have been hampered by the lack of a
The conformational changes we observed in this region and the neighboring 70’s loop that includes Y74 and Y75 thus likely explains why E104.v2 can destabilize the small interface while E104.v1 cannot, despite possessing identical CDR sequences. This effect was confirmed with SEC analysis ...
By modifying the amino acid sequence of the shortened hinge region however we have found that Clq binding, and thus complement mediated cytolysis can be further improved. In particular in IgG3 molecules having human constant regions, where the hinge region has been modified to approximate the sequ...
FIG. 21 is a perspective showing of the cabinet body or cabinet wall in the region of the bore hole which receives the first hinge part or a bushing-like intermediate body of said hinge part; FIGS. 22a to 22d are a top view of the first hinge part and of the intermediate body surroun...