a, Overview of the study design. The image was created using BioRender.com.b, UMAP embedding of scRNA-seq data for all 895,460 cells. Thirteen cell types were defined by RNA expression of marker genes (Extended Data Fig.1a).c, Graph representation of Nhoods identified by Milo. Nodes are...
This should state clearly the main conclusions and provide an explanation of the importance and relevance of the case, data, opinion, database or software reported. Declarations All manuscripts must contain the following sections under the heading 'Declarations': Ethics approval and consent to particip...
There is increasing demand from the public for direct-to-consumer (DTC) genetic tests, and the US Food and Drug Administration limits the type of health-related claims DTC tests can market. Some DTC companies provide raw genotyping data to customers if requested, and these raw data may include...
2.1. Role of Exosomes of MSCs in AKI Cells of distinct types have been confirmed to secrete exosomes that may be significant in the onset and development of AKI, especially mesenchymal stem cells (MSCs). MSCs are derived from a wide range of sources, including bone marrow, adipose tissue, ...
There have been conventional treatments such as surgical intervention, physical and behavioral therapy, Hyperbaric Oxygen therapy (HBOT), and medical management of associated conditions (Bennett et al., 2012; Xiong et ...
Given the different proportions of AS types in each lineage, a higher relevance has been given to proteomic expansion associated with ES in animals [1], whereas in plants the focus has been put mainly into the regulation of gene expression by IR coupled to NMD [9,10,11]. The effects of...
The genus Oryza is a model system for the study of molecular evolution over time scales ranging from a few thousand to 15 million years. Using 13 reference genomes spanning the Oryza species tree, we show that despite few large-scale chromosomal rearrangements rapid species diversification is mirro...
Population-based biobanks with genomic and dense phenotype data provide opportunities for generating effective therapeutic hypotheses and understanding the genomic role in disease predisposition. To characterize latent components of genetic associations,
Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide an