High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and...
Patterns of invasionMost high-grade serous carcinomas (HGSC) of the ovary are advanced stage tumors with early recurrences. However, some tumors do not recur and have a better survival. We identified such cases of HGSC and compared those with the cases that recurred and assessed the ...
Ovarian cancer has traditionally been thought to develop from the ovarian surface epithelium (OSE) or cortical inclusion cysts (CICs), but the recent data suggest that a majority of advanced high-grade serous carcinomas (HGSC) likely originate from the epithelium of the distal fallopian tube1. S...
Ovarian carcinoma remains one of the deadliest malignancies in the United States, rating amongst the top five causes of death for women between 40 and 79 years old [1]. High-grade serous ovarian carcinoma (HGSOC) is the most prevalent and most aggressive histotype of ovarian cancer. Clinica...
Ovarian cancer is a heterogeneous group of cancers that differ by cell of origin and genomic features. High-grade serous ovarian cancer (HGSOC) is the commonest histiotype and is characterized by extreme genomic complexity and dysregulation of DNA damage repair pathways, particularly homologous ...
Many high-grade serous carcinomas (HGSCs) of the pelvis are thought to originate in the distal portion of the fallopian tube. Serous tubal intra-epithelial carcinoma (STIC) lesions are the putative precursor to HGSC and identifiable in 50% of advanced stage cases. To better understand the mole...
Overall, high-grade serous carcinoma (HGSC), also known as high-grade serous ovarian cancer, is estimated to be 50–60% of all ovarian malignancies [10,11]. Moreover, HGSC accounts for a large majority (63.4%: 7837/28,118) of all ovarian carcinomas, and advanced-stage HGSC represents ...
High grade serous ovarian carcinoma (HGSOC) accounts for ~ 70% of ovarian cancer cases. Non-invasive, highly specific blood-based tests for pre-symptomatic screening in women are crucial to reducing the mortality associated with this disease. Since
High grade serous ovarian carcinomas originate in the fallopian tube. Nat Commun. 2017;8(1):1093. Article PubMed PubMed Central Google Scholar Ahmed AA, Etemadmoghadam D, Temple J, Lynch AG, Riad M, Sharma R, et al. Driver mutations in TP53 are ubiquitous in high grade serous ...
Recent studies have suggested that the most common and lethal type of 'ovarian' cancer, i.e. high-grade serous carcinoma (HGSC), usually arises from epithelium on the fallopian tube fimbriae, and not from the ovarian surface epithelium. We have developed Ovgp1-iCreER T2 mice in which the ...