Whileuric acidcan cause gout andkidney disease, it is also a known antioxidant—reducing tissue damagingoxidative stress—and is an essential factor for the living body. It can be found inlung tissuebut, until now, its function in the lung was unknown. Because of this, and the fact that m...
Results Females with a blood stasis constitution had higher UA levels, lower HDLC levels, and higher UHR in serum, suggesting a higher risk of metabolic abnormalities. Analysis of the gut microbiome revealed two distinct enterotypes dominated by Bacteroides or Prevotella. Intriguingly, blood stasis sub...
RESULTS: There were 65.5% males, mean age of 50.29 +/- 6.39 years and body mass index (BMI) of 21.68 +/- 2.64 kg/m2. The mean value of estimated GFR was 53.86 +/- 6.29 ml/min/1.73 m2. In subjects with serum uric acid fourth quartile displayed significantly higher BMI, higher ...
Lipids, uric acid, fasting glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and high sensitive C-reactive protein (hs-CRP) were also assessed.#Results:Effective arterial elastance and end-systolic elastance increased significantly with body mass index (r = 0.35 and ...
We monitored the impact of HUA on phospho-ERK and phospho-p38 levels in myocardial tissue from an acute hyperuricaemia mouse model established by potassium oxonate treatment. RESULTS: HUA decreased cardiomyocyte viability and increased ROS production in cardiomyocytes; pre-treatment with N-acetyl-L-...
These results demonstrated that high uric acid promoted the urinary metformin excretion and decreased the plasma metformin concentration, in vivo and in vitro studies provide a possible explanation for this is that high uric acid could upregulated the expression of renal metformin transporters OCTs and...
The results showed that the detection limits ( S/ N=3) were 3 nM for Ampero-ED and 6 nM for Coulo-ED, and the linearity of the calibration curves of 60–6000 nM had correlation coefficients exceeding 0.999. In addition, the total analytical time was 10 min. In the sample preparation ...
Based on the PEG-catalase treatment results, H2O2 may be the final ROS product re- sponsible for endothelial cell impairment. Our data sug- gest that PEG-catalase and epalrestat decrease H2O2 production, thereby protecting endothelial function. Discussion Uric acid (UA), which is generated in ...
The method was found to be precise and accurate. There was a good correlation between the results of the new method and those of spectrophotometric methods for measuring creatinine and uric acid in human serum. 展开 关键词: HYDROGENATION ISOTOPE EXCHANGE TRITIUM ALANINE ISOTOPOMER ...
Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation 2007; 115: 2526–2532. Article CAS Google Scholar Chang HY, Pan WH, Yeh WT, Tsai KS . Hyperuricemia and gout in Taiwan: results from the Nutritional and Health Survey in Taiwan (1993...