From 2000 through 2008, Lexicon Pharmaceuticals performed high-throughput mouse knockout and comprehensive phenotypic analyses (Genome5000™) for >4 650 genes. KO strategies (described below) involved both gene trapping,7using the OmniBank® I embryonic stem (ES) cell library, and homologous r...
Conclusion: Dietary high-fat lard intake induces significant thyroid dysfunction and abnormal morphology in rats, which can not be corrected by short-term dietary modification. Keywords: high-fat lard diet; thyroid gland; hypertriglyceridemia; hypothyroidism; ER stress; TSH; TTF-1; NIS; lipotoxicity...
In conclusion, combined exposure to HFD and arsenic induced hypothyroidism via reduction of thyroid hormones and enhancement of plasma TSH and T3 uptake levels concomitant with hypolipidemia, hyperleptinemia, hyperadiponectinemia, induction of oxidative stress, and reduction of GSH levels....
Alterations in circulatory levels of total T4 (TT4), total T3 (TT3), free T4 (FT4), free T3 (FT3), thyrotropin (TSH) and T3 uptake (T3U) were studied in ma... M Basu,K Pal,AS Malhotra,... - 《International Journal of Biometeorology》 被引量: 32发表: 1995年 ...
- Initial orders: CBC, BMP, EKG, TSH, free T3/T4, bHCG -> shows hyperthyroidism- Orders after results: 24-hr radioiodine uptake, when increased add propranolol, mehtimazole -> f/u in 4 wks- Final orders: at f/u CBC, stop MMA, do radioiodine, f/u in 1 mo- Counseling: Safe ...
Urine iodine is very high; thyroid 24 hr 131Ⅰ uptake is very low; serum T4, T3 and TSH are all within normal range.Two other villages(Group B) in the vicinity are similarly examined, the inhabitants are also fishers, but they drink old fashioned shallow well water, the iodine content ...
In conclusion, combined exposure to HFD and arsenic induced hypothyroidism via reduction of thyroid hormones and enhancement of plasma TSH and T3 uptake levels concomitant with hypolipidemia, hyperleptinemia, hyperadiponectinemia, induction of oxidative stress, and reduction of GSH levels....
In the medium containing 1.0 m m and less K, the growth of KD was significantly suppressed, suggesting that OsHAK5 greatly contributed to K absorption under limited K conditions. Although Cs suppressed the growth of KD and WT, stronger inhibition was observed on KD. Both KD and WT ...
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