High-throughput screening For ReFRAME library screening, 10 nL of 2 mM DMSO stock concentrations of compound were prespotted into 5 µL of assay medium (RPMI with 2% FBS, 10 mM HEPES, 1 mM sodium pyruvate, 25 mM D-glucose (Sigma), and 1% penicillin/streptomcycin) in white...
Methods for high-throughput drug combination screening and synergy scoring. In:von Stechow L, editor.Cancer systems biology: methods and protocols. New York, NY: Springer; 2018. p. 351-98.He LY, Kulesskiy E, Saarela J et al (2016) Methods for High-Throughput Drug Combination Screening and...
Glioblastoma multiforme (GBM) is the most common and malignant of all human primary brain cancers, in which drug treatment is still one of the most effective treatments. However, existing drug discovery and development methods rely on the use of conventi
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING COMB CHEM HIGH T SCR 最新影响因子:1.714 期刊ISSN:1386-2073 CiteScore:N/A 出版周期:Bimonthly 是否OA:YES 出版年份:1998 期刊官方网址:http://benthamscience.com/journal/index.php?journalID=cchts 自引率:9.00% 研究方向:化学-生化研究方法 出版地区:...
throughput screening (HTS) into chemical decision-making may transform “toxicology from a predominantly observational science at the level of disease-specific models in vivo to a predominantly predictive science focused on broad inclusion of target-specific, mechanism-based, quantitatively relevant ...
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING COMB CHEM HIGH T SCR 最新影响因子:1.714 期刊ISSN:1386-2073 CiteScore:N/A 出版周期:Bimonthly 是否OA:YES 出版年份:1998 期刊官方网址:http://benthamscience.com/journal/index.php?journalID=cchts 自引率:9.00% 研究方向:化学-生化研究方法 出版地区:...
The objective of this study was to identify and validate drugs with antineoplastic effect in ACC cells using a novel quantitative high-throughput drug screening (qHTS) technique. Methods A quantitative high-throughput proliferation assay of 2,816 clinically approved drugs was performed in the NCI-...
Schmitt M, Pawlita M: High-throughput detection and multiplex identification of cell contaminations. Nucleic Acids Res. 2009, 37 (18): e119-10.1093/nar/gkp581. Article PubMed Central PubMed Google Scholar Vichai V, Kirtikara K: Sulforhodamine B colorimetric assay for cytotoxicity screening. ...
Article PubMed Central CAS PubMed Google Scholar Smilkstein M, Sriwilaijaroen N, Kelly JX, Wilairat P, Riscoe M: Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening. Antimicrob Agents Chemother. 2004, 48 (5): 1803-1806. 10.1128/AAC.48.5.1803-...
R. High-throughput screening: today’s biochemical and cell-based approaches. Drug Discov. Today 25, 1807–1821 (2020). Article CAS PubMed Google Scholar Ha, J., Park, H., Park, J. & Park, S. B. Recent advances in identifying protein targets in drug discovery. Cell Chem. Biol. ...