Hyperandrogenism is a medical condition characterized by high levels of androgens in women, and less commonly in men. The presentation of hyperandrogenism
MENABSTRACT Previous prospective cohort studies have shown that serum levels of sex steroids and sex hormone‐binding globulin (SHBG) associate with nonvertebral fracture risk in men. ... 查看全部>>doi:info:doi/10.1002/jbmr.2718Vandenput, Liesbeth...
Insulin resistance lowers the levels of sex hormone-binding globulin (SHBG), a protein that usually binds to testosterone and keeps it inactive. When SHBG levels drop, more active testosterone is available in the body. Additionally, high insulin levels can prompt the adrenal glands to produce more...
男性BMI的增加与血浆SHBG浓度的降低有关, 从而导致睾酮水平降低, 伴随雌激素浓度升高[41~44]. 而青春期男性的睾丸发育及成年后男性睾丸次级精母细胞的减数分裂及精子细胞的成熟都必须依赖于睾酮, 且睾丸内高水平的睾酮是维持血睾屏障(blood-testis barrier, BTB)与支持细胞以及支持细胞与生殖细胞之间连接所必须的. ...
High SHBG levels were strongly associated with an increased risk of prostate cancer in a study on almost 300 men. Another study found a slightly increased risk, but only in younger men [90, 91].However, a meta-analysis of 8 studies and another study (on almost 1000 men) failed to find...
Serum levels of estradiol (total, free and bioavailable), estriol, testosterone (total, free and bioavailable), sex hormone binding globulin (SHBG), and AFP were examined during first and third trimesters. We found that the black mothers, rather than the white mothers, had significantly higher ...
and steatosis70, whereas de novo fatty acid synthesis induced by sucrose, fructose or glucose has been shown to reduce the hepatocyte-produced sex hormone binding globulin (SHBG)71, which is thought to interact with ERα to regulate the transport of estrogens (and testosterone) into tissues in ...
In several prospective studies and randomised controlled trials, weight loss through low-calorie or low-fat diets increased erectile function and testosterone levels in men17,18,19. However, the mechanisms of weight loss on low-calorie diets improving male fertility are incompletely characterized. A ...
Within both PCOS and control groups, SHBG levels in obese women were lower than in normal-weight women. Estradiol concentrations were decreased in both normal-weight and obese PCOS women when compared with their respective controls. On the other hand, DHEAS concentrations were not different in ...
after adjusting for age, body mass index, smoking status, alcohol drinking, regular exercise, diastolic blood pressure, fasting plasma glucose, and total cholesterol level.Conclusions: The TG/HDL ratio was inversely associated with testosterone and SHBG levels in middle-aged and elderly Korean men.do...