Recent exceptional longevity (EL) genome wide association studies have facilitated estimation of an individual’s polygenic risk score (PRS) for EL. We tested the hypothesis that individuals with high ELPRS have a low prevalence of MetS. Participants were from five cohorts of middle-aged to older...
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High-risk fertility behaviour (HRFB) remains a significant public health concern in Nigeria, contributing to increase in maternal and child morbidity and mortality. The existence of HRFB presents significant barrier to accomplishing the Sustainable Development Goals. The objective of this study was to...
The ZERO Childhood Cancer Precision Medicine Program PRecISion Medicine for Children with Cancer (PRISM) trial used whole-genome sequencing (WGS) (paired tumor-germline), and transcriptomic sequencing and DNA methylation, to identify molecular targets in high-risk cancers. Therapeutic options for potentia...
The proportion of threatened and/or commercial species projected to be at risk within each MPA across European sea regions is close to zero under the SSP1–1.9 (Fig. 2). Under the SSP5–8.5, several regions emerge as hotspots where a substantial proportion of species are projected to be at...
HSV-1 is also closely related to HSV-2, a human pathogen with an increased risk with human immunodeficiency virus-1 (HIV-1) infection [21, 22]. Reactivation can occur in response to various stimuli, such as immunosuppression, stress, or hormonal changes, which are symptomatic; however, ...
[36]. Rare copy-number variants (rCNVs) include deletions and duplications that occur infrequently and confer substantial risk for disease. This study quantified the properties of haploinsufficiency (deletion intolerance) and triplosensitivity (duplication intolerance) by analysing rCNVs from nearly one ...
coli, continue to be among the most common pathogens linked to perinatal infection/inflammation and increased risk of perinatal brain injury [38, 39]. We sought to reproduce features of Gram-negative infection/inflammation using repeated increasing doses of LPS infusions to promote a chronic ...
Scoping reviews follow a structured process similar to systematic reviews; however, their general purpose is to identify and map the available evidence, thus they generally do not involve an assessment of risk of bias14. Our specific aims were to: (1) provide a broader overview of studies ...
In this backdrop, we examined whether tobacco control interventions at the population-level are more effective in increasing life expectancy among Australians compared to interventions targeting a high risk group or a combination of the two when smoking prevalence is reduced to 10 and 0% respectively...