To deal with the curse of dimensionality, three regularization schemes are used: a reduced-rank model, penalization of the covariance matrix, and regularization of the basis-expanded predictor set. The latter allows us to flexibly model associations while controlling for overfitting. The modeling ...
λ is a regularization parameter which The proposed methodology The proposed joint dimension reduction and dictionary learning framework is introduced in details. Fig. 1 illustrates the basic idea of the proposed method, which is composed of the following parts. First, to preserve the nonlinear ...
The genes influencing the survival of HGSOC patients were filtered based on log-rank p-value < 0.05 and hazard ratio (HR) either greater than 1.1 or less than 0.9. This pre-filtering strategy, akin to approaches used in previous studies [13, 18], aims to mitigate noise (number of ...
Compared to the CSI:FingerID score, COSMIC improved the average rank of correct annotations from 56.5 to 33.9 when searching the biomolecule structure database (see Supplementary Fig. 2 for CSI:FingerID results without structure–disjoint evaluation). Fig. 2: Separation by hit score for different ...
hunter-gatherers’ subsistence, and thus high-ranked. To understand which prey species were high ranked, we (i) identify what mammals were generally present in the ecosystems of the study period, (ii) estimate their (post-encounter) profitability, and (iii) rank them according to their ...
hunter-gatherers’ subsistence, and thus high-ranked. To understand which prey species were high ranked, we (i) identify what mammals were generally present in the ecosystems of the study period, (ii) estimate their (post-encounter) profitability, and (iii) rank them according to their ...
Kaplan-Meier curves and the log-rank test were utilized to compare the OS or PFS of various ECMscore groups. Using univariate and multivariate Cox regression models, the prognostic factors were evaluated. Using the “timeROC” package, the time-dependent AUC was determined. A two-sided P ...
Significance testing was performed using the Wilcoxon rank sum test and a Bonferroni corrected significance threshold of 0.05/315. Models using more than one input feature were constructed using logistic regression with elastic net regularization [23, 24] implemented in the glmnet and caret [25] R ...
www.nature.com/scientificreports OPEN Feasibility and robustness of dynamic 18F-FET PET based tracer kinetic models applied to patients Received: 23 March 2018 Accepted: 7 September 2018 Published: xx xx xxxx with recurrent high-grade glioma prior to carbon ion irradiation Charlotte Debus ...
The performance tests were used to score and rank teams (Fig. 1e and Supplementary Table 16). The developer and user groups were not compared because they received different study instructions. The team scoring was validated using an independent glycoprotein-centric site-specific profiling test (Sup...