5-oxoprolinemia (pyroglutamic acid, PGA) in the absence of acetaminophen use has been rarely reported as a cause for high anion gap metabolic acidosis. We investigated the prevalence and risk factors for elevated PGA concentrations among hospitalized patients with high anion gap metabolic acidosis:...
n-acetylglutamine (nacgln) is a modified amino acid (an acetylated analogue of glutamine) and is a metabolite present in normal human urine. the decomposition products of nacgln have been identified by nmr and hplc-ms as n-acetyl-l-glutamic acid, n-(2,6-dioxo-3-piperidinyl) acetamide,...
Mu C, Yang Y, Luo Z et al (2015) Metabolomic analysis reveals dis- tinct profiles in the plasma and urine of rats fed a high-protein diet. Amino Acids 47:1225-1238Mu C, Yang Y, Luo Z, et al. (2015) Metabolomic analysis reveals distinct profiles in the plasma and urine of rats...
PYROGLUTAMIC acid5-oxoprolinemia (pyroglutamic acid, PGA) in the absence of acetaminophen use has been rarely reported as a cause for high anion gap metabolic acidosis. We investigated the prevalence and risk factors for elevated PGA concentrations among hospitalized patients with high anion gap ...
A growing number of case reports and case series describe high anion gap metabolic acidosis (HAGMA) following paracetamol exposure with subsequent detection or measurement of 5-oxoproline (also called pyroglutamic acid) in blood, urine, or both. Typically 5-oxoprolinuria or 5-oxoprolinemia ...
generally observed in positive ion mode atm/z233 and 179 via neutral losses of glycine 75 D and pyroglutamic acid 129 Da, respectively [24]. For the 6.8 min isomer, E2-d4exchanges one deuterium (Figure 7) upon oxidation to form an ortho-quinone in position 2. GSH is then added at pos...