The aim of this study was to test the validity of the progesterone challenge test (PCT) for this purpose. The test was performed in 100 postmenopausal women at risk, and the results were compared with histopathology findings. Atrophic endometrium was found only in the PCT-negative cases, while...
a lack of estrogens in postmenopausal women is associated with an increased risk of weight gain, cardiovascular diseases, low-grade inflammation, and cancer. Estrogens act with leptin to regulate energy homeostasis in females. Leptin-deficient mice (ob/ob) exhibit morbid obesity and insulin resistance...
Progesterone inhibits arterial smooth muscle cell proliferation Mortality from atherosclerotic cardiovascular disease is lower in premenopausal women than in age-matched men. It is also lower in postmenopausal women who... WS Lee,JA Harder,M Yoshizumi,... - 《Nature Medicine》 被引量: 334发表: 199...
Progesterone receptor (PR)-interacting compounds in the environment are associated with serious health hazards. However, methods for their detection in environmental samples are cumbersome. We report a sensitive activity-based biosensor for rapid and reliable screening of progesterone receptor (PR)-interact...
Despite the fact that a small percentage of peri en postmenopausal women have mild elevations in human chorionic gonadotrophin (hCG) concentrations (40 IU/L) given her menopausal state. Although a pregnancy or a malignancy was unlikely on the basis of stable hCG levels, elevated gonadotrophins and...
Results Expected age- and postmenopause- related declines in salivary estradiol (E), progesterone (P), dehydroepiandrosterone (DHEA) and testosterone (T) levels were observed. This was most pronounced for DHEA and T, which were also the only postmenopausal hormone levels significantly associated ...
They both have two stages of Th1 escalation, but young men have higher progesterone than aged postmenopausal women (Zumoff et al., 1990, Muneyyirci–Delale et al., 1999). Young males: In young men infected with SARS–CoV–2, the rise in Th1 due to old age is not there. Hence, ...
Randomised clinical trials in early breast cancer have shown that tamoxifen reduces recurrence and mortality in women with oestrogen receptor (ER)- or progesterone receptor (PR)-positive cancers and it is recommended for a 5-year period (Scottish Intercollegiate Guideline Network Guidelines, 2005; Ear...
Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status—a meta-analysis. Int J Cancer. 2009;124(3):698-712.PubMedGoogle ScholarCrossref 22. Hartz A, He T, Rimm A. Comparison of adiposity measures as risk factors in postmenopausal women. J Clin ...
Progestins, especially high dose medroxyprogesterone acetate, are receiving renewed attention in treatment of advanced breast cancer. The trials reviewed here indicate that such regimens may be as effective as tamoxifen in postmenopausal unselected cases, and that they may be effective as second-line tr...