From 1692 records screened, 99 trials were included. Most were multicentre studies performed in North America and Europe that mainly had evaluated medical devices from the specialty of diabetology. Most had enrolled adolescents and 39% of trials included both children and adults. Randomized controlled ...
"COVID-19 has amplified the inequalities in global health and this clearly extends to who leads and who participates in randomizedclinical trials," Professor Tong said. "We need to now look at prioritizing research that is relevant to low andmiddle income countries, and building research infrastru...
The purpose of this study is to compare registration, publication, and outcome reporting among pivotal clinical trials that supported FDA approval of high-risk (Class III) medical devices before and after the U.S. Food and Drug Administration (FDA) Amendment Act (FDAAA) was enacted in 2007. ...
The closed-loop decoding performance for the 2D and 4D decoder was compared using 529 trials (3 days) for the 2D decoder and 524 trials (6 days) for the 4D decoder (Fig.1e). For the 2D decoder, the mean acquisition time was 1.33 ± 0.03 s, the target acquisition rate was...
Mark Bolton, head of global public policy and senior legal counsel for Greenwich Biosciences, opposed the bill. His company develops cannabinoid-derived medicines that can gain FDA approval after trials and says that level of caution and rigor won’t be followed if states cover all medical marijua...
Similarly, adult human atrial and ventricular slices provide a versatile and potentially high throughput model for pre-clinical trials of novel therapeutic strategies. Acute administration of β-adenergic stimulation showed expected response on the APD and CV. Unexpectedly, acute versus chronic α1-...
Another AbbVie hopeful, venetoclax, being tested for the blood cancer multiple myeloma, has also disappointed in clinical trials. Investors have noticed the struggles—AbbVie’s stock has plunged more than 27% in the past 12 months, underperforming most of its peers. ...
In contrast to SGLT2i and GLP-1 RA, numerous CV outcomes trials (CVOTs) have pointed to a generally neutral effect with dipeptidyl peptidase-4 inhibitors (DPP-4i) [22]. However, despite the high prevalence of cardiorenal risk in patients with T2D [23,24,25], DPP-4i remain more widely...
Thus, well-designed prospective trials of patients with COVID-19-related AHRF who receive a trial of HFNC are needed to address this issue. 4.4. Value of the ROX Index for Monitoring Patients Treated with HFNC When HFNC is applied to patients with AHRF, clinicians may want to predict ...
Future prospective multicenter clinical trials of large cohorts of patients are needed to validate the results and optimize the protocol. Author Contributions K.-H.W. conceived the study. T.-F.W. and J.-P.L. contributed to patient care. Y.-H.C. wrote the manuscript. All authors have ...