High-order chromatin structure and the epigenome in cellular senescenceChandra, TamirNarita, Masashi
Although the CTCF/cohesin complex preferentially targets hypomethylated DNA, it remains unclear whether the CTCF/cohesin-mediated high-order chromatin structure is affected by DNA methylation during tumorigenesis. We found that DNA methylation downregulates the expression of prostaglandin-endoperoxide synthase ...
High-order three-dimensional (3D) interactions between more than two genomic loci are common in human chromatin, but their role in gene regulation is unclear. Previous high-order 3D chromatin assays either measure distant interactions across the genome or proximal interactions at selected targets. To...
Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure. J Biol Chem. 2012;287(14):10738–52. Article CAS PubMed PubMed Central Google Scholar Han X, Yu D, Gu R, Jia Y, Wang Q, Jaganathan A, et al. Roles of the BR...
Nucleosome phasing was also lost surrounding CTCF binding motifs in the knockdown cells (Figure 6F), providing strong evidence that CTCF binding (rather than some aspect of DNA ”programming” of chromatin structure) is required for nucleosome positioning at these locations. Finally, we asked whether...
Characteristics of human sperm chromatin structure following an episode of influenza and high fever: a case study. J Androl 2000; 21: 739-46.Evenson DP, Jost LK, Corzett M, Balhorn R. Characteristics of human sperm chromatin structure following an episode of influenza and high fever: a case...
This result suggests that open chromatin structure maintained by the MLL family proteins and long-range chromatin organization by CTCF may contribute to chromosome breaks and may explain why certain translocations are found in the cancers of specific cell types. Prediction of Novel Transcription Units ...
[26–28]. Alternatively, the mutation could disrupt the local chromatin structure, or interaction of chromatin with the nuclear matrix, in a manner that affects the expression of other genes. Finally, it is possible that there is an uncharacterized non-coding RNA in the critical region that is...
Unigenes involved in ‘chromatin structure and dynamics’ and ‘defense mechanisms’ in the heat-tolerant tall fescue had more two times enrichment than in the heat-sensitive tall fescue at 0 HAT and 12 HAT, respectively (Figure 2a, b). Under high-temperature stress, higher enrichment of the...
scNanoHi-C: a single-cell long-read concatemer sequencing method to reveal high-order chromatin structures within individual cells Article 28 August 2023 Main In mammalian cells, interphase chromosomes are hierarchically organized into large compartments containing topologically associating domains (TADs)...