Employing primary cultures of astrocytes which seem to constitute a valid model of their in vivo counterparts, it has been demonstrated that this cell type is likely to be of importance in terminating the transmitter activity of GABA. It has been shown that the transport carrier in astrocytes is...
Purpose 纬-Aminobutyric acid (GABA) is recognised as a potential metabolic bioactive food ingredient with increasing evidence of its effects on the gut-brain axis and systemic metabolic health. Different lactic acid bacteria are capable of producing GABA, particularly strains of Lactobacillus brevis. ...
Several studies have identified the effects of methamphetamine (MA) on central dopaminergic neurons, but its effects on enteric dopaminergic neurons (EDNs) are unclear. The aim of this study was to investigate the effects of MA on EDNs and intestinal motility. Male Sprague–Dawley rats were random...
The duration of OFF suppression increased with stimulation intensity, independent of ON-effects. Antagonism of GABA(A)function did not directly effect OFF suppression duration.CONCLUSIONS: The present results suggest that "rational" seizure control protocols using intermittent high-frequency electrical ...
Effects of prenatal ethanol (4 g/kg.d) exposure on serum glucose, serum insulin concentrations and insulin resistance index (IRI) in the rat offspring. (A) Male glucose concentration; (B) Male insulin concentration; (C) Male IRI; (D) Female glucose concentration; E: Female insulin concent...
HPTS and ε-PL synergistically decreased the number of surviving spores and increased the release of the intracellular components in the spore suspension, with the maximal effects from treatment with 550 MPa at 75°C plus 0.3% ε-PL. Maximum fluidity and permeability of the cell inner membrane ...
Membrane proteins, including ion channels, receptors and transporters, are often composed of multiple subunits and can form large complexes. Their specific composition in native tissues is difficult to determine and remains largely unknown. In this study, we developed a method for determining the subun...
Many studies have already shown the potential effects of HIIT on cognitive functions. The purpose of this trial is to evaluate the cognitive effects of HIIT on individuals with MA dependence. Methods and analysis A total of 240 individuals with MA dependence will be randomly assigned to the HIIT...
distinguished prognostically from low seizure frequency-TLE by differentially increased specific leukocyte gene expression involved in GABA (γ-aminobutyric acid) inhibition and NMDA (N-Methyl- d-aspartate) receptor signaling. We also explore what appears to be a consistent pattern of processes involving...
Previous studies have shown that a HFD can influence serotonergic signaling. For instance, male rats fed a HFD for 12 weeks had higher levels of serotonin (5-hydroxytryptamine; 5-HT) in the hippocampus [5]. However, the mechanisms underlying the effects of HFD on serotonergic signaling are not...