High levels of extracellular ATP lead to different inflammatory responses. CD39 and CD73 expression were increased in COVID-19 patients. Cytokines IL-2, IL-6, IL-10, and IL-17 also were altered in these patients. The purinergic system may be a possibility target to SARS-CoV-2 treatments....
ATP levels decreased to 26% of control during ischemia and recovered to 80% of control during the initial 4 hours of reperfusion; these changes were followed by a second phase of decline. CONCLUSIONS: Results show an important relationship between ischemia-induced depletion of high-energy ...
Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by me... With L-carnitine a markedly improved recovery of the high energy phosphates (e.g. increased PCr /P i ratios) was found. With acety...
Right: Measurement of ATP levels of four types of islets from live and dead control groups and cryopreservation groups (VR and conventional). One-way ANOVA with Games–Howell post hoc test was used to compare groups, and P values from informative pairwise comparisons are shown (n = 3–...
(Cai et al., 2017;Chung et al., 2012;Takeda et al., 2014;Wu et al., 2016). Moreover, radiation therapy and certain chemotherapeutic agents such ascyclophosphamideinduce an immunogenic tumor cell death that elicits an initially protective immune response dependent onHMGB1and ATP release into ...
1f) and by millimolar concentrations of ATP, which has previously been reported to act as a biological hydrotrope that solubilizes aggregation-prone proteins in aqueous solutions28 (Supplementary Fig. 1g). Taken together, these results demonstrate that the human trimeric RPA complex has a propensity...
including the generation of free radical/reactive oxygen species (ROS) that further damages cellular membranes [13], [14], alterations in intracellular Ca2+ homeostasis [13], [15], mitochondrial and DNA damage, generation of oxidative stress and exhaustion of ATP, resulting in cardiomyocytes apoptos...
AExpression ofCgKCSinY. lipolyticapo1g.BThe control strain po1g.CExpression ofAtFAE1in po1g.DExpression ofBtFAE1in po1g.ECo-expression ofAtFAE1,BtFAE1andCgKCSin po1g.FDiagram of fatty acid metabolism related to multiple organelles and subcellular localization ofCgKCS. ACL, ATP-citrate lyase...
For example, RBCs regulate vascular function via releasing adenosine triphosphate (ATP) and modulating nitric oxide (NO)-dependent vasorelaxation [4]. In addition, RBCs regulate the levels of key circulating chemokines, such as monocyte chemoattractant protein (MCP)-1, through binding to the Duffy ...
6(c). These data suggest that the increased levels of ATP are responsible for the enhanced ATP uptake in the melanoma cells in response to the MW radiation, as shown in Fig. 5(d). Download: Download high-res image (365KB) Download: Download full-size image Fig. 6. Molecular analysis ...