Blood transferrin receptor (TR) level is largely determined by the quantum of erythropoiesis and by intracellular iron content of the cells of the erythroid lineage. Hence, a high serum TR level has been found to be useful in distinguishing iron deficiency anemia (IDA) from anemia of chronic ...
Transport proteins:Hemoglobincarries oxygen, andtransferrincarries iron in the blood;myoglobincarries oxygen in the muscles;ferritinstores iron, andcytochromescarry electrons in the respiratory chain in the cells;albumincarries certain ions, hormones, vitamins, bilirubin, drugs and toxins via the blood. A...
humans ascending to high altitude (HA, defined as 2500 m and above sea level) inhale fewer oxygen molecules per breath. However, the oxygen percentage in the atmosphere remains static. This condition of hypobaric hypoxia is the principal driver...
level of transferrin decreases in inflammation. The metal binding properties of transferrin have a great influence on the biochemistry of plutonium in humans. Transferrin has a bactericidal effect on bacteria, in that it makes Fe3+ unavailable to the bacteria. Carbohydrate deficient transferrin ...
NIH 3T3 cells exhibited the same sensitivity to growth inhibition by ET-18-OCH3 as Swiss 3T3 cells and had a similar level of PIPLC. v-sis NIH 3T3 cells were relatively resistant (greater than 3-fold) to growth inhibition by ET-18-OCH3 and had a cytosolic PIPLC activity more than ...
The most likely cause of the rapid accumulation of iron in the retina after ph-IOP injury was free iron release from endogenous bound iron. Ferritin is the main intracellular iron storage protein. The level of FTH1 (a subunit of ferritin) decreased sharply at 1 h after ph-IOP injury (...
transferrin saturation, soluble transferrin receptor (sTfR), hepcidin, red blood cell mean corpuscular volume (MCV), and mean cell Hb (MCH).ResultsWith a ZPP cutoff level of at least 100渭mol/mol heme, subclinical iron deficiency was present in 6.9% of male donors and in 9.8% of female do...
As expected, MLL-rearranged infant ALL and pediatric noninfant ALL samples displaying high MCL-1 expression were significantly (P < .05) more resistant to prednisolone that were patients expressing lower levels of MCL-1 (Figure 2B,D). Interestingly, high level MCL-1 expression was also ...
Using high-content microscopy and an automated image analysis pipeline, we screened a diversity library of 28,864 small molecules and identified a lead compound, BCH-HSP-C01, that restored ATG9A pathology in multiple disease models, including patient-derived fibroblasts and induced pluripotent stem ...
Interestingly, despite the increasing level of lactate concentration and depletion in cell viability, the glucose level was remained detected in the group without any medium replacement in C/MR(−). This showed that instead of glucose starvation, lactate accumulation was the main limiting factor for...