female reproductive system. Likewise, testosterone is referred to as the male sex hormone for the roles it plays in male sexual development and function. It's true that women and people assigned female at birth (AFAB) have much higher levels of estrogen, but they have some testosterone, too....
After intrathecal injection of the GPR30 agonist G1, female rats with low estrogen and plantar incisions continued to exhibit significant hyperalgesia until 48h post-incision. In high estrogen level rats with plantar incisions, intrathecal injection of GPR30 antagonist G15 significantly attenuated ...
Elevated expression of FREM1 in breast cancer indicates favorable prognosis and high‐level immune infiltration statusbiomarkerbreast cancerFRAS1㏑elated Extracellular Matrix 1 (FREM1)immune infiltrationprognosisBreast cancer (BC) poses one of the major threats to female's health worldwide. Immune ...
After 14 weeks of HFD exposure, normalized increase of body weight reached similar levels between male and female mice. Overall, both sexes under HFD displayed a decrease of orexigenic neuropeptides expression while an increase in Pomc gene expression was observed only in female mice. In addition,...
The objective of this study was to determine the interactive actions of estrogen deficiency and an HFS diet on bone properties in female rats and the potential mechanisms that might be involved. The interactive effects of ovariectomy and an HFS diet on bone properties, bone biochemical markers and...
Leptin and estrogen signaling pathways interact to influence reproduction and energy metabolism. High levels of E2 are associated with increased leptin sensitivity in both male and female rodents23. In contrast, decreased estrogens in ovariectomized mice and postmenopausal women increases leptin resistance,...
In humans, melatonin is expressed in female reproductive organs, such as the ovary, placenta, and uterus12. In the ovary, melatonin is presented in the follicular fluid. The levels of melatonin in follicular fluid are positively correlated with the size of the follicle13. Interestingly, the ...
located on the top of each kidney. Some DHEA is also produced by the testes and ovaries, and plays an important role in the production of the male sex hormone testosterone and the female sex hormone estrogen. DHEA also has a role in the making ofinsulingrowth factor-1 that controls muscle...
Women generally have higher levels of HDL, or "good," cholesterol because the female hormone estrogen tends to raise HDL levels. This is why most women tend to have lower cholesterol levels than men. That is, until menopause, after that, triglyceride levels start to rise. As women approach ...
(p-adj < 0.01). The entire ranked list of detected transcripts was used for gene set enrichment analysis36using WebGestalt37, and we observed numerous highly significant gene sets enriched in the patient clusters including MYC target genes, G2M checkpoint genes, E2F target, and Estrogen Response...