Lactic acidosis is caused by either your cells producing too much lactic acid or not being able to filter out this excess – or sometimes both. Often, this happens due to a disease that causes low oxygen levels in the body or disrupts the metabolism of lactic acid. These include diseases o...
The yellow balls and sticks denote the lactylated lysine residues, and the red balls and sticks denote the lactic acid molecule. (d) The changes in the accessibility of each protein surface were calculated via the above molecular modeling. (e) BV-2 cells were treated with 20 mM lactate for...
Higher serum caspase-cleaved cytokeratin-18 levels during the first week of sepsis diagnosis in non-survivor patients. Clin Chem Lab Med. 2017;55:1621–9. Article CAS PubMed Google Scholar Bantel H, Lügering A, Heidemann J, Volkmann X, Poremba C, Strassburg CP, Manns MP, Schulze-Ost...
Since then the role of lactate (lactic acid) has fascinated physiologists, biochemists, and intensive care physicians. Hyperlactatemia is one of the most common metabolic abnormalities in critically ill patients, and numerous studies have established the use of blood lactate levels and/or lactate ...
O’Hanlon et al80 found that lactic acid was highly efficacious at reducing the levels of 17 different BV-associated organisms in vitro; specifically, it is the protonated form of this compound that is effective, as opposed to the lactate anion. Furthermore, these authors showed that this ...
The choice of continuous renal replacement therapy (CRRT) anticoagulation program for patients at high risk of bleeding has always been a complex problem in clinical practice. Clinical regimens include regional citrate anticoagulation (RCA) and nafamosta
This process has generated 44 recommendations related to pediatric COVID-19 patients presenting with respiratory distress or failure, sepsis or septic shock, cardiopulmonary arrest, MIS-C, those requiring adjuvant therapies, or ECMO. Evidence to explain the milder disease patterns in children and the ...
[36]. Nevertheless, considering the frequent presence of metallic taste, mucositis and nausea in patients treated with metronidazole, vancomycin is preferred in oncohematological patients [26]. Finally, due to the possibility of sepsis in neutropenic and other immunocompromised patients, probiotics should...
Background Higher plasma plasminogen activator inhibitor-1 (PAI-1) levels have been reported in septic patients. However, some questions remain unanswered, such as whether there is an association between plasma PAI-1 levels and sepsis severity and mortality, and inflammation state during the first ...
Objective The purpose of this study was to investigate the effect of high volume hemofiltration (HVHF) combined with capacity recovery for patients with multiple organ dysfunction syndrome (MODS) induced by sepsis, and analyze the corresponding application value in arterial blood lactic acid level, ...