High lactate dehydrogenase levels at admission for painful vaso-occlusive crisis is associated with severe outcome in adult SCD patients. Clin Biochem 2012; 45:1578-1582Stankovic Stojanovic K, Steichen O, Lefevre G, Bachmeyer C, Avellino V, Grateau G, Girot R, Lionnet F. "High lactate ...
Serum lactate dehydrogenase (LDH) is elevated in various diseases.To analyze serum LDH as a distinguishing clinical biomarker and as a predictor of in-hospital outcome in admitted medical patients.We analyzed a cohort of all 158 patients with very high isolated LDH (LDH > or = 800 IU/ml with...
In the blood vessel, CRP is involved in endothelial dysfunction that consequently leads to atherosclerotic plaque development and progression3. Multiple studies4,5,6,7already confirmed a correlation between increased CRP levels and (long-term) cardiovascular health. Therefore, incorporating CRP into CVD ...
we investigated patient cases with D-dimer levels below the reference level of ≤1 µg/mL, which constitutes 39.1% of all COVID-19 patients (n = 110). As shown in Fig.5b, significant levels of platelet aggregate concentrations are evident. Also, as shown ...
The aim of study was to observe the effect of increased lactate levels during high-intensity interval training (HIIT) on protein lactylation, identify the target protein, and investigate the regulatory effect of lactylation on the function of the protein
Adaptations to the LCD included lower muscle and liver glycogen content, decreased rate of glycogen breakdown during exercise, decreased lactate production, and elevated blood ketone levels. In addition to these substrate changes, the LCD caused increased enzyme activities of muscular 3-hydroxyacyl-CoA ...
coli codon optimized lactate dehydrogenase [GenBank: BAE80313.1] from L. mesenteroides subsp. mesenteroides (ldhLm) to generate pDNC9 and pDNC10, respectively. Plasmids constructed and used in this work are described in Table 1 as well as publicly available in the JBEI Registry (https://...
High-altitude cerebral edema (HACE) is considered an end-stage acute mountain sickness (AMS) that typically occurs in people after rapid ascent to 2500 m or more. While hypoxia is a fundamental feature of the pathophysiological mechanism of HACE, em
methylpropionate transaminase (q = 6.07e−4) and glutamate dehydrogenase (q = 0.040). Additionally, when results of our mmvec analysis were incorporated into our hypothesis, a high co-occurrence of five bacterial species with one pathway-embedded metabolite (phenylalanine) was revealed. ...
Eligible patients were 33 consecutive hg B-NHL patients responding to first-line chemotherapy and fulfilling at least one of the following criteria: stage III or IV, bulky disease, elevated lactate dehydrogenase or failure to achieve complete remission (CR). Twenty-two of 33 patients (67%) had...