A high-intensity statin is recommended for the secondary prevention of cardiovascular diseases (CVD). However, real-world evidence of the effectiveness of rosuvastatin following acute coronary syndrome (ACS) is scarce. This retrospective cohort study included patients diagnosed with ACS to compare ...
Accordingly, we designed the ASTEROID trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) to examine the effects of high-intensity statin therapy on IVUS-derived measures of coronary disease progression. Rosuvastatin is the most recently ...
5 Patients were treated with rosuvastatin, 10 mg, or atorvastatin, 20 mg, for the moderate-intensity statin therapy and rosuvastatin, 20 mg, or atorvastatin, 40 mg, for the high-intensity statin therapy. In the treat-to-target group, the target LDL-C level chosen was the lowest recomm...
High-intensity statin is recommended for patients undergoing percutaneous coronary intervention (PCI), and ezetimibe is recommended to be added in patients not achieving low-density lipoprotein cholesterol (LDL-C) targets. Moderate-intensity statin plus ezetimibe can reduce LDL-C levels similar to high...
et al. CYP3A4*1B and CYP3A5*3 SNPs significantly impact the response of Egyptian candidates to high-intensity statin therapy to atorvastatin. Eur J Med Res 29, 539 (2024). https://doi.org/10.1186/s40001-024-02109-7 Download citation Received10 June 2024 Accepted14 October 2024 Published...
beneficiaries 66 to 75 years of age taking a low/moderate-intensity statin with (n = 6718) and without (n = 6414) DM who titrated to a high-intensity statin dosage (i.e., atorvastatin 40 or 80 mg, or rosuvastatin 20 or 40 mg) following an AMI hospitalization in 2014...
(73%). All the patients were candidates for high-intensity statin therapy. The participants were either predisposed to or already had atherosclerotic cardiovascular disease (ASCVD). Approximately two-thirds (62%) of the subjects were on low-dose aspirin as a prophylactic therapy for CVD events. ...
Statin use was defined as the first prescription of statins on or after the index date. According to the British NICE guideline,11 high-intensity statin use was defined as atorvas- tatin ≥20 mg/day, rosuvastatin ≥10 mg/day, and simvastatin 80 mg/day, medium-intensity as atorvastatin 10...
Medicare beneficiaries aged 66 to 75 years (n = 29 932) and older than 75 years (n = 27 956) hospitalized for myocardial infarction between 2007 and 2012 who filled a high-intensity statin prescription (atorvastatin, 40-80 mg, and rosuvastatin, 20-40 mg) within 30 days of...
Patients were randomized to receive biweekly subcutaneous alirocumab (150 mg; n = 148) or placebo (n = 152), initiated less than 24 hours after urgent percutaneous coronary intervention of the culprit lesion, for 52 weeks in addition to high-intensity statin therapy (rosuvastatin, 20 ...