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The roles of B and plasma cells in the pathogenesis of inflammatory bowel disease (IBD) are largely unrevealed. Data on the characteristics of IgG4 in patients with IBD are scarce. In this case-control study, serum IgG4 levels were comparable between patients with IBD and healthy individuals,...
High-fat (HF) diet is commonly used to induce metabolic disease in rodents, as it causes both obesity and prediabetes. HF diet can have profound effects on the brain, some of which are sex dependent. For example, we have shown that HF diet impairs adult hippocampal neurogenesis in female,...
Taken together, 2–8 weeks after vaccination 2, 22 individuals with hematologic cancer showed negative or low-level anti-spike IgG levels, corresponding to 39% of the 57 individuals included in the statistical analysis, whereas all 25 matched healthy individuals displayed robust anti-spike IgG respo...
In order to determine the potential prolongation of intervals between infusions following the administration of 500 mg/kg of intravenous immunoglobulin, 11 patients were studied. This high-dose therapy was well tolerated and resulted in a modest prolongation of therapeutic IgG levels when compared with...
The reduction of CD4+ T lymphocytes, B cells activation and high levels of inflammatory cytokines (IL-6/IL-8/TNF/IL-1β), plasma LPS, soluble CD14, anti-Leishmania IgG3 and low leptin levels are involved in the immunopathogenesis of VL, most associated with severe VL. Despite relapses ...
Previous BCR repertoire analysis reported higher SHM levels of IgG B cells prior to vaccination in older adults [11]. With the paired gene expression data, we were able to examine the pre-vaccination SHM frequencies between age groups separately for each isotype and cell type. We computed heavy...
Immunohistochemical staining of VISTA revealed elevated expression levels in high grade gliomas. Representative staining intensity of VISTA protein was detected in human glioma tissues (Moroccan cohort) using immunohistochemistry assay. (a) Negative control staining in glioma case with Rabbit IgG Isotype Con...
in mice. We report that sucrose intake induces sexually dimorphic effects in liver, adipose tissue, and the microbiome; differences concordant with steatosis severity. We show that when steatosis is decoupled from impairments in insulin responsiveness, sex is a moderating factor that influences sucrose...
Epidermal growth factor (EGF) receptors contribute to the development of malignant glioma. Here we considered the possible implication of the EGFR ligand epiregulin (EREG) in glioma development in relation to the activity of the unfolded protein response