卵巢癌是最致命的妇科恶性肿瘤,具有侵袭性强、预后差的特点,其中高级别浆液性卵巢癌(highgrade serous disease, HGSOC)是最常见、最致命的,确诊患者有70%以上在确诊后5年内死亡,而I期HGSOC的5年总生存率在90%以上。HGSOC在不同阶段的治愈率差异很大,这使得早期诊断HGSOC有可能提高生存率。多年来,为HGSOC开发...
海外直订Tumor Microenvironment High Grade Serous Ovarian Cancer 高级别级别浆液卵巢癌的肿瘤环境科普读物 683元 (包邮,需用券)价格:783元满600减20每300减40淘金币可抵3%满1600减50满300减5满1000减30海外直订The Tumor Microenvironment of High Grade Serous Ovarian Cancer 高级别浆液性卵巢癌的肿瘤微环境20...
Salomon-Perzynski A, et al. High-grade serous ovarian cancer: the clone wars. Arch Gynecol Obstet. 2017;295(3):569-76.Salomon-Perzynski, A., Salomon-Perzynska, M., Michalski, B. & Skrzypulec-Plinta, V. High-grade serous ovarian cancer: the clone wars. Archives of Gynecology and ...
High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and...
低级别浆液性卵巢癌(Low-grade serous ovarian cancer,简称LGSOC)是一种卵巢癌比较少见的亚型,癌细胞的生长速度较慢,细胞异型程度较低。相对于高级别浆液性卵巢癌(High-grade serous ovarian cancer),LGSOC的病情发展通常较缓慢,但复发风险很高,大约85%的患者会遭遇复发,而且会对化疗耐药。
high-grade serous ovarian cancerPARP inhibitorsOvarian cancer is a heterogeneous group of cancers that differ by cell of origin and genomic features. High-grade serous ovarian cancer (HGSOC) is the commonest histiotype and is characterized by extreme genomic complexity and dysregulation of DNA ...
High grade serous ovarian carcinoma (HGSOC) is a highly heterogeneous disease that typically presents at an advanced, metastatic state. The multi-scale complexity of HGSOC is a major obstacle to predicting response to neoadjuvant chemotherapy (NACT) and understanding critical determinants of response....
High-grade serous ovarian carcinoma (HGSOC) is the most aggressive type of ovarian cancer, often diagnosed at advanced stages. Molecularly, HGSOC shows high degree of genomic instability associated with large number of genetic alterations. BRD4 is the 4t
(2016) A clinically applicable molecular classification for high grade serous ovarian cancer based on hormone receptor expression. Scientific Reports 6: 25408.Feng Z, Wen H, Bi R, Ju X, Chen X, Yang W, Wu X. A clinically applicable molecular classification for high- grade serous ovarian ...
Malignant abdominal fluid (ascites) frequently develops in women with advanced high-grade serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor prognosis1. To comprehensively characterize the HGSOC ascites ecosystem, we used single-cell RNA sequencing to profile ~11,000 ce...