High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and...
Uterine round ligament depositInguinal canalMetastasisHigh-grade serous carcinomaThe major pathway of metastasis in Epithelial ovarian cancer is through direct exfoliation of cells in peritoneal cavity. Isolated distant metastasis especially in round ligament is hardly reported.#We present a rare case of ...
She initially presented with an abnormal Pap smear, and, on a subsequent endometrial curettage, detached fragments of high-grade adenocarcinoma were identified. Upon hysterectomy and bilateral salpingoophorectomy, invasive high-grade serous carcinoma was found in the proximal stump of a ligated ...
Bagby C, Ronnett BM, Yemelyanova A, Maleki Z, Kuhn E, Vang R (2013) Clinically occult tubal and ovarian high-grade serous carcinomas presenting in uterine samples: diagnostic pitfalls and clues to improve recognition of tumor origin. Int J Gynecol Pathol 32(5):433–443.https://doi.org/...
The cell-of-origin of high grade serous ovarian carcinoma (HGSOC) remains controversial, with fallopian tube epithelium (FTE) and ovarian surface epithelium (OSE) both considered candidates. Here, by using genetically engineered mouse models and organoids, we assessed the tumor-forming properties of...
The two most prevalent subtypes of epithelial ovarian carcinoma (EOC) are ovarian clear cell carcinoma (OCCC) and high-grade serous ovarian carcinoma (HGSC). Patients with OCCC have a poor prognosis than those with HGSC due to chemoresistance, implying t
MRI for differentiating ovarian endometrioid adenocarcinoma from high-grade serous adenocarcinoma.MRI for differentiating ovarian endometrioid adenocarcinoma from high-grade serous adenocarcinoma.doi:10.1186/s13048-015-0154-2To investigate magnetic resonance imaging (MRI) features for differentiating ovarian endomet...
High-grade tumors (n=21) consisted of 8 grade 3 endometrioid adenocarcinomas, 8 non-endometrioid adenocarcinomas (4 serous, 3 clear cell, and 1 mixed serous-clear cell adenocarcinoma), and 5 mixed endometrioid and non-endometrioid adenocarcinomas. All low-grade tumors were grade 1 and 2 ...
The survival of patients with MMMT was also lower than that of patients with the special histologic variants of endometrial carcinoma, serous adenocarcinoma and clear cell carcinoma, which are recognized for their unusually aggressive clinical behavior. These results indicate that uterine malignant mixed...
(2016) 114, 417–426 | doi: 10.1038/bjc.2015.471 Keywords: CDCP1; CUB-domain containing protein 1; high-grade serous ovarian cancer; patient-derived xenograft; SKOV3 Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer Brittney ...