With the PSA screening pendulum swinging away from testing, there is a risk that successes in reducing prostate cancer mortality will be lost. A screening strategy that preferentially targets HG PCA and avoids detection of LG disease has the potential to maintain the mortality reduction while ...
High-Grade Prostate Cancer More Likely To Be Found in Sicker MenJody Charnow
In this high-risk setting, the combination of external-beam radiotherapy with a brachytherapy boost (EBRT+BT) accompanied by androgen-deprivation therapy (ADT) led to reductions in prostate cancer–specific mortality and to better outcomes overall compared to either radical prostatectomy or the combinat...
R. Comparative risk-adjusted mortality outcomes after primary surgery, radiotherapy, or androgen-deprivation therapy for localized prostate cancer. Cancer 116, 5226–5234 (2010). Article PubMed Google Scholar Tewari, A. et al. Long-term survival in men with high grade prostate cancer: a ...
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209–249 (2021). Article PubMed Google Scholar Rebbeck, T. R. Prostate cancer disparities by race and ethnicity: from nucleotide to neighborhood. ...
Finasteride and High-Grade Prostate Cancer in the Prostate Cancer Prevention Trial: Lucia MS, Epstein JI, Goodman PJ, et al (Univ of Colorado Denver and Health Sciences Ctr, CO; Johns Hopkins Hosp, Baltimore, MD; Fred Hutchinson Cancer Research Ctr, Seattle, WA; et al) J Natl Cancer Inst...
Will the Scottish Cancer Target for the year 2000 be met? The use of cancer registration and death records to predict future cancer incidence and mortality... Cancer mortality data reflect disease incidence and the effectiveness of treatment. Incidence data, however, reflect the burden of disease ...
Prostate cancer (PrCa) genomic heterogeneity causes resistance to therapies such as androgen deprivation. Such heterogeneity can be deciphered in the context of evolutionary principles, but current clinical trials do not include evolution as an essential
The researchers found that adjuvant radiation therapy was associated with significantly lower all-cause mortality. Among men with high-grade prostate cancer that extended outside the prostate, the risk of death was reduced by two-thirds. Ten years after radical prostatectomy, the rate of all-cause ...
Overall, they found no significant differences in high-grade prostate cancer risk between users and non-users; however, they found that long-term users had a greater odds of clinically and pathologically more advanced disease than non-users. 1 Patients who used 5αRIs for > 3 years had ...