High-Grade Prostate Cancer More Likely To Be Found in Sicker MenJody Charnow
With increased screening for prostate cancer, we have noted a greater number of patients with small foci of Gleason score 7 or greater prostate cancer on needle biopsy. The significance of these findings is unknown. We studied 57 men with small foci of Gleason score 7 or greater on needle bi...
Overall, they found no significant differences in high-grade prostate cancer risk between users and non-users; however, they found that long-term users had a greater odds of clinically and pathologically more advanced disease than non-users. 1 Patients who used 5αRIs for > 3 years had ...
There are several blood- and urine-based assays that provide prognostic information regarding risk of high-grade prostate cancer at initial biopsy. These include the US Food and Drug Administration (FDA) approved prostate health index blood test (PHI) (Beckman Coulter, Inc), which combines total ...
Objective: To evaluate the utility of apparent diffusion coefficient (ADC) values from DWI in identifying intermediate and high grade prostate cancer (patients harboring Gleason 4 and/or 5 components in their radical prostatectomy specimens). Methods: We retrospectively analyzed the DWI of 54 patients...
Long-term survival in men with high grade prostate cancer: a comparison between conservative treatment, radiation therapy and radical prosta- tectomy-a propensity scoring approach. J Urol. 2007;177:911-915.Tewari A, Divine G, Chang P, et al. Long-term survival in men with high grade ...
Beaver Creek, CO--An in-depth pathologic review of specimens collected from participants in the Prostate Cancer Prevention Trial (PCPT) revealed that the reported increase in high-grade prostate cancer was most likely due to increased early detection of high-grade tumors in men receiving finasteride...
Objective: This study compared survival of prostate cancer patients with low prostate specific antigen level (PSA ≤ 10 ng/ml) and high-grades of Gleason score (GS) of 8–10 with different treatment options (i.e., radical prostatectomy [RP], external beam radiotherapy [EBRT...
"The type of aggressive prostate cancer that we focused on has sometimes been regarded as so high risk that some patients even forgo local treatments like surgery or radiation because they are worried that the cancer has already spread and is incurable," said lead study author Amar Kishan, MD...
Finasteride and High-Grade Prostate Cancer in the Prostate Cancer Prevention Trial: Lucia MS, Epstein JI, Goodman PJ, et al (Univ of Colorado Denver and Health Sciences Ctr, CO; Johns Hopkins Hosp, Baltimore, MD; Fred Hutchinson Cancer Research Ctr, Seattle, WA; et al) J Natl Cancer Inst...