Infiltrating ductal carcinomaTwo-dimensional difference gel electrophoresisLarge-scale proteomics will play a critical role in the rapid display, identification and validation of new protein targets, and elucidation of the underlying molecular events that are associated with disease development, progression ...
According to histopathological results, lung cancer can be subdivided into non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC).105,106SCLC is a high-grade neuroendocrine lung carcinoma that was once considered a molecularly homogeneous malignancy. Transcriptional diversity exists among...
One approach is the use of tumor-infiltrating lymphocytes (TILs), which entails the isolation and expansion of a subgroup of intratumoral lymphocytes followed by reinfusion. Promising results have been reported with TIL therapy in solid tumors, including those for cervical carcinoma4,5, colorectal ...
Key words infiltrating ductal carcinoma (IDC); high-mobility group box 1 protein (HMGB1); clinical staging; lymph node; estrogen receptor (ER); human epidermal growth factor receptor 2 (HER-2) Correspondence to: Shiying Yu. Email: syyu@tjh.tjmu.edu * Supported by a grant from the Innova...
Similarly, whilst intratumoural HEVs have been associated with high tumour-infiltrating lymphocyte (TIL) counts as well as lymph node (LN) metastasis in oral and pharyngeal squamous cell carcinoma (OPSCC) patients, their functional role has not been directly examined by intravital imaging. See [...
such as Tumor Infiltrating Lymphocytes (TILs), engineered T Cell Receptor (TCR) T cell therapy, and Chimeric Antigen Receptor (CAR) T cell therapy [2]. These approaches have shown significant clinical effectiveness in treating hematologic malignancies [3]. However, adoptive T cell therapy is not...
these cells also expressedTNFRSF17(B cell maturation antigen) which is essential for the survival of long-lived plasma cells [74].TNFRSF17expression was restricted to plasma cell high tumours regardless of the presence of other tumour-infiltrating lymphocytes (T cells, memory B cells) and linked...
Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma. Cancer Lett. 477, 131–143 (2020). Article CAS PubMed Google Scholar Miao, B. P. et al. Nasopharyngeal cancer-derived microRNA-21 promotes immune suppressive B cells. Cell Mol. ...
Lung adenocarcinoma (LUAD) is one of the sole causes of death in lung cancer patients. This study combined with single-cell RNA-seq analysis to identify tumor stem-related prognostic models to predict the prognosis of lung adenocarcinoma, chemotherapy ag
usually within 2 cm of the original lesion.18–20 Glioma cell invasion is likely an early event in disease progression as elevated normal tissue invasion is often observed in low- grade infiltrating astrocytomas.18 Pediatric brain tumors are the second most common type of pediatric cancer after ...