This study compared clinical outcomes associated with Pap smear reports of atypical squamous cells cannot exclude HSIL (ASC-H) and those associated with "low-grade smears containing occasional cells suggestive of HSIL" (LSIL-H). In Alberta, women with ASC-H are referred for colposcopy, and women...
* High-grade squamous intraepithelial lesion (HSIL): moderate to severe dysplasia. Who should have colposcopy? (Clinical Inquiries) Results of Pap tests were reported using Bethesda System categories: normal; infection, inflammation, or reactive changes; atypical squamous cells of undetermined significance...
Upon hysterectomy and bilateral salpingoophorectomy, invasive high-grade serous carcinoma was found in the proximal stump of a ligated fallopian tube. Morphologically identical tumor extensively involved the endocervical glands. A single focus of malignant cells was also found at the surface of the ...
Cohort analysis of n = 54 dysplastic pap smears for polymorphology of cells, anisonucleosis, structure of the nucleus, signs of tissue destruction, nucleus/plasma relation and signs of tumordiathesis. Each criteria was classified into three stages: The first with little evidence for dysplasia (...
Atypical squamous cells - cannot exclude a high-grade squamous intraepithelial lesion (ASC-H). Few squamous cells with enlarged nuclei with multinucleation (arrow) in a dense hemorrhagic background (Pap stain, 100x original magnification) Full size image Fig. 3 Low-grade squamous intraepithelial les...
High grade squamous intraepithelial lesions are usually diagnosed with a Pap smear or colposcopy. A Pap smear is a type of test used to detect abnormal changes in cells. This is done by scraping away loose cells from the cervix, spreading (smearing) it on a glass slide, and examining...
For instance, miR-18a showed increased expression following the suppression of HPV16 and 18 E6 or E7 oncoproteins during the transformation of HeLa cells [20]. Additionally, miR-34a played a role in distinguishing between low grade dyspla- sia and CC, particularly in patients with HPV16 and 18...
The objective of this study was to determine the risk of a clinically significant lesion associated with the diagnosis of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H) on cervical cytology (Pap smear). This was a retrospective, observational, descriptive stu...
This leads to the HPV infection being maintained, because infected cells do not undergo apoptosis, but on the contrary experience activation of their pro-proliferative genes [11, 12]. The specificity of cervical screening might therefore be improved by the detection of biomarkers distinctive of ...
In that trial, hrHPV-positive women 35 years and older and those with results positive for atypical squamous cells of undetermined significance were referred directly to colposcopy; colposcopy rates were 3 times higher for cotesting compared with cytology (10.6% vs 3.0%).14,25,26 Of those ...