PALMITIC acidAGINGCELLULAR agingAUTOPHAGYTYPE 2 diabetesGLUCOSEADIPOSE tissuesPANCREASCell senescence is a basic aging mechanism. Previous studies have found that the cellular senescence in adipose tissue and o
Astragalus polysaccharide improve the proliferation and insulin secretion of mouse pancreatic β cells induced by high glucose and palmitic acid partially through promoting miR-136-5p and miR-149-5p expression Bioengineered, 12 (2) (2021), pp. 9872-9884, 10.1080/21655979.2021.1996314 View in Scopus...
Long-term exposure to hyperglycemic conditions leads to β-cell dysfunction, particularly mitochondrial dysfunction, and inflammatory and oxidative stress responses, which are considered the primary causes of β-cell death and the hallmarks of diabetes.
High glucose levels did not alter placental lipase or transporter expression or the profile and abundance of fatty acids, but triglyceride levels were higher (p < 0.05), suggesting reduced β- oxidation. DM did not affect placental protein expression or fatty acid profile. Triglyceride levels ...
High glucose increased reactive oxygen species (ROS) generation, and this was suppressed by pretreating delphinidin or the antioxidant N-acetyl cysteine. NADPH oxidase (NOX) 1 was upregulated by high glucose, but pretreatment with delphinidin abrogated this upregulation. Increased mitochondrial ...
No differences were observed in the ability of skeletal muscle to metabolize palmitic acid or glucose substrates. High fat feeding did significantly decrease substrate metabolic flexibility (as measured by both acid soluble metabolites and total metabolites), and GSE partially restored lost metabolic ...
Cells were then incubated ± palmitic acid (: 400μM, 12h) to induce insulin resistance followed by incubation ± insulin (: 1000 nM) before measurement of glucose and FA kinetics. In line with the presence of insulin resistance, FA treatment raised basal GU (122.2±5.2% vs 230.0±18.8%;...
Furthermore, the increase in fat mass in HFD mice was also accompanied by glucose intolerance and higher insulin and leptin plasma concentrations compared to SD mice [26]. Our findings regarding food intake data support a satietogenic effect of a HFD and could reflect adaptative feedback ...
Schwann cells (SCs) maintain the physiological function of peripheral nerves and promote the repair and regeneration of injured nerves. Inhibiting the apoptosis of SCs through various pathological pathways in a high-glucose environment plays an important role in developing DPN. Therefore, inhibiting the...
High glucose 1. Introduction Glomerular visceral epithelial cells or podocytes are highly specialized cells that cover the outer layer of the glomerular basement membrane (GBM) and play a crucial role in the regulation of glomerular filtration. For these reasons podocyte injury has drawn much attention...