The aim of this study was to investigate whether high glucose and/or high insulin produces cellular insulin resistance in human adipocytes and, if so, to evaluate the time course and content of key proteins in the insulin signaling pathway. Subcutaneous fat biopsies were taken from 27 nondiabetic...
The aim of this study was to investigate whether high glucose and/or high insulin produces cellular insulin resistance in human adipocytes and, if so, to evaluate the time course and content of key proteins in the insulin signaling pathway. Subcutaneous fat biopsies were taken from 27 ...
In conclusion, sesamin has anti-oxidative effect on the L02 hepatocyte model of insulin resistance induced by high glucose/high insulin. Sesamin is a lignan (Fig. 1) with a molecular weight of 354.36. Sesamin has been shown to have multiple beneficial health effects including promotion of ...
1)high glucose and insulin高糖高胰岛素 1.NO pathway involves in the anti-hypertrophic effects of fenofibrate induced by high glucose and insulin一氧化氮参与非诺贝特抗高糖高胰岛素诱导的心肌肥大 英文短句/例句 1.PPAR-α involves in cardiomyocyte hypertrophy induced by high glucose and insulinPPAR-α参与...
These findings suggest that high glucose and high insulin conditions promoted the proliferation and invasion of MCF‑7 cells by upregulating IRS1 and activating the Ras/Raf/ERK pathway. 展开 关键词: type 2 diabetes mellitus, breast cancer, insulin receptor substrate 1, proliferation, invasion ...
and Signal Pathway. Cardamonin Ameliorates Insulin Resistance Induced by High Insulin and High Glucose through the mTOR and Signal Pathway.Cardamonin Ameliorates Insulin Resistance Induced by High Insulin and High Glucose through the mTOR and Signal Pathway.doi:10.1055/s-0032-1328325...
Objective To explore the molecular mechanism of glucocorticoid and high glucose-induced insulin resistance(IR).Methods Isolated rat adipocytes were cultured for 24h at 5 or 25 mM glucose with or without dexamethasone (Dex) 0 3μM. Then the glucose uptake , the phosphorylation of tyrosine of insul...
High blood glucose(hyperglycemia) and the phenomenon of insulin resistance are being considered as the major factorscontributing to an increased risk of AD. However, the mechanisms involved in this interaction remainunclear.Objective: High glucose has been shown to increase release of pro-inflammatory ...
In the gastrocnemius muscle, HFCS impaired insulin and AMP-activated protein kinase signaling pathways and reduced GLUT-4 and GLUT-5 expression and membrane translocation. GW0742 administration induced PPAR-?? upregulation and improvement in glucose and lipid metabolism. Diet-induced activation of ...
Our studies focus on ERp46, an endoplasmic reticulum (ER) component, and analyze its involvement in glucose toxicity and in insulin production. Differences in pancreatic β-TC-6 cell proteome under conditions of low vs. high glucose were examined by proteomic approaches, including twodimensional gel...