It has become increasingly clear that low levels of antibiotics present in many environments can select for resistant bacteria, yet the evolutionary pathways for resistance development during exposure to low amounts of antibiotics remain poorly defined. Here we show thatSalmonella entericaexposed to sub-...
TAD evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function Article Open access 07 December 2023 Introduction How the DNA packs into the nucleus and coordinates functional activities is a long-standing question in biology. Recent studies have shown ...
from the University of York; the Austrian Science Fund (FWF) SFB F43 to AB and MJ and [P26333] to MK; The French Agence Nationale de la Recherche grant ANR-16-CE12-0032 to MC; the Japan Science and Technology Agency (JST), the Core Research for Evolutionary Science and Technology (...
To address this issue, this study proposes a hyper-parameter-evolutionary latent factor analysis (HLFA) model. Its main idea is to build a swarm by taking the hyper-parameters of every single LFA-based model as particles, and then apply particle swarm optimization (PSO) to make its both ...
The comprehensive characterization of the sika deer genome along with the transcriptomic data presented herein provides a framework used to elucidate its evolutionary events, revealing the mechanism of the unique attributes and tannin adaptation. Through detailed genomics and transcriptomics analyses, we ...
and the genetic variation inherent within each population reflects its evolutionary and breeding history. Finally, considering our materials and genotypes are available to the public, we anticipate more QTLs or trait-linked SNP markers will be discovered in different environmental conditions, which could...
For CpG loci to act as a molecular clock, the loci should not be subject to strong evolutionary selection or cell-specific regulation. We compared the proportion of the 1,794 fCpG sites that were associated with a specific gene to the 428,511 CpG sites that were not identified as fluctuati...
Eighteen randomly selected genes were used to confirm their expression patterns of the Illumina RNA-Seq results by quantitative real-time PCR (qPCR, Figure 6, Additional file 9). Nine genes, encoding SNF-related serine/threonine-protein kinase (SnRK2-1, SnRK2-2), transcription factor TGA, smal...
DENV3-CH53489, which was purified to cryoEM quality, was diluted by a factor of 1:1000 in cold RPMI containing 2% FBS and then incubated at 4 or 29 or 37 °C for 30 min (when incubated at 29 and 37 °C, virus will turn into clubSPs). Next, it was further incubated on...
(right). The zinc-coordinating residues originate from entirely different locations, indicating the two enzymes do not have a common evolutionary origin.cHistidine 109 that ligands Zn1in Endo IV is positioned to the ‘right’ of the active site and pulls Zn1away from the center line.dIn Dna...