Some medications can cause high estrogen levels in men. These include certain prescription drugs for treating acne, heart disease, and prostate cancer. Testosterone replacement therapy (TRT) or illegal anabolic steroids can also cause high estrogen levels. That’s why adoctor prescribes Arimidex for ...
While, T47D cell is an estrogen receptor alpha (ERα) positive moderately aggressive breast cancer cell line, MDA-MB-231 cell belongs to the triple negative breast cancer subtype with very aggressive cancer metastatic properties. Both these cell lines used extensively in cancer research ...
In the present work, we analyzed the effect of a decellularized, multi-component ECM derived from an aggressive human breast cancer cell line (MDA-MB-231) on a human breast cancer cell line with an epithelial phenotype (MCF-7). Our results showed that MDA-ECM triggered EMT in MCF-7 ...
This reduction in poststroke deficits might be associated with the rise in BDNF expression in both plasma and brain hemispheres through PGC1α/ERRα (estrogen receptor-related receptor alpha) pathway, known to be involved in both mitochondrial biogenesis and neurotrophin expression [89,153]. In ...
MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer. Clin. Cancer Res. 2016, 22, 935–947. [CrossRef] [PubMed] 24. Lupia, M.; Cavallaro, U. Ovarian cancer stem cells: Still an elusive ...
Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces α9-nicotinic acetylcholine receptor expression in human breast cancer cells. Breast Cancer Res. Treat. 2011, 129, 331–345. [CrossRef] [PubMed] 22. Paleari, L.; Sessa, F.; Catassi, A.; Servent, D.; ...
It is a heterogeneous and complex pathology, characterized by the non-expression of estrogen receptors (ER) and progesterone receptors (PR), and the absence of epidermal growth factor receptor-2 (HER2) over-expression or ERBB-2 amplification [3,4]. Recently, five molecular subtypes of TNBC ...
It is classified as a natural xenoestrogen, or a chemical that mimics estrogen in the body. Genistein has been shown to exhibit potent anticancer effects and synergize with certain cancer therapeutics [71–73]. However, it has also been shown to directly inhibit the anti-cancer activity of ...