Dose effects were studied in 27 patients treated with 0, 500, 1000, 1500 and 2250 mg/day of metformin. The effect of dosing frequency was compared in 56 patients with 1500 mg/day of metformin administered either twice or three times per day. Results: Significant dose-dependent improvement in...
Fig. 1. Effects of treatment supplementations on FISN (A) and HOMA-B (B) at baseline and after 3 months study period. FISN, Fasting insulin; HOMA-B, homeostasis model assessment of β‐cell function; AE group, high dose vitamin A plus E group; AEZ group, combined high-dose vitamin A...
The aim of this double-blind, placebo-controlled, multinational, five-arm study was to investigate the dose-response relationship of acarbose as a first-line drug in the treatment of type 2 diabetes (non-insulin dependent) over a range of minimal and maximal doses according to the European re...
The aim of this review is to create an up-to-date overview of the most important research conducted within the field of high-dose VitC and cancer therapy. First, the use of high-dose VitC mono- and combination therapy in the pre-clinical and clinical setting is discussed, followed by a ...
High-dose glucocorticoid treatment vs. glucocorticoid replacement in immune checkpoint inhibitor associated hypophysitis (CORTICI): an open, randomised controlled trial Verena Theiler-SchwetzChristian TrummerLisa SchmittAngelika TerbuchBarbara Obermayer-PietschErika RichtigStefan Pilz...
Development and validation of rapid rp-hplc and green second-derivative uv spectroscopic methods for simultaneous quantification of metformin and remogliflozin in formulation using experimental design 2020, Separations Design of experiments in liquid chromatography (HPLC) analysis of pharmaceuticals: Analytics...
Metformin, often taken to manage diabetes or metabolic disease, can alter leptin levels, insulin sensitivity, and fat oxidation and storage. After six months on metformin, the man lost about 18 pounds with no adverse effects.More studies are neededto determine whether metformin should play a ...
In addition, the skeletal Gilz mRNA expression was decreased by more than 50% from baseline in mice at three days after one dose of intravenous administration of (DSS)6-AZD8329, while such inhibition on Gilz mRNA expression was enhanced dose-dependently from 3 mg/kg to 10 mg/kg (...
Metformin 333 (6.5) 4190 (81.8) 600 (11.7) a Missing due to empty fields in database and no submitted data. b Missing, no data submitted in one study in patients with non-small-cell lung carcinoma. c Includes antiarrhythmic and antihypertensive medications; complete data missing due to incom...
Metformin is an old drug widely used for type 2 diabetes patients [32, 33], it is very effective in lowering blood glucose in patients with type 2 diabetes with minimal side-effects. Metformin is also being recommended in the treatment of obesity and metabolic syndrome [34, 35]. In ...