It has been shown that high-dose therapy including high-dose melphalan may be considered as the treatment of choice in newly diagnosed patients. The purpose of this report is to review and summarize the clinical information on IV high-dose melphalan in patients with multiple myeloma and to ...
网络高剂量化学治疗 网络释义 1. 高剂量化学治疗 有学者报告,以高剂量化学治疗(high-dose melphalan)合并自体骨髓移植来治疗多发性骨髓瘤,可以得到较高的缓解率。甚… tw.myblog.yahoo.com|基于15个网页
Bortezomib-dexamethasone (BD) and high-dose melphalan (HDM) are effective for systemic light-chain (AL) amyloidosis, but have not been compared in detail. We retrospectively investigated patients treated with BD or HDM at our center between September 2001 and June 2016. Among 234 patients, 20 ...
Early discharge after high-dose melphalan and peripheral blood stem cell reinfusion in patients with hematological and non-hematological disease. The purpose of this study was to analyse our experience of early discharge 2 days after high-dose melphalan (HDM) (Day-1) followed by peripheral blood...
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High-dose melphalan and stem cell transplantation (HDM/SCT) is effective for selected patients with AL amyloidosis, with high rates of complete hematologic response and potential for improved organ dysfunction. Data on tolerability and response to HDM/SCT in patients with ESRD due to AL amyloidosis...
Nishihori T, Hassoun Y, Zhang L, Shain K, Alsina M, Kharfan- Dabaja MA (2014) High-dose melphalan produces favorable re- sponse in a patient with multiple myeloma and coexisting essential thrombocythemia with JAK2 mutation. Bone Marrow Transplant 49(1):148-149...
June 13, 2011 (London, United Kingdom) — Contrary to expectation, progression-free survival in patients with multiple myeloma is longer in patients who receive high-dose melphalan (Alkeran, GlaxoSmithKline) and undergo autologous stem cell transplantation (ASCT) than in those treated with the ...
Twenty-six patients also received irradiation to the site of primary tumour. The Rapid VAC regimen was well tolerated and largely administered as an out-patient. There was one toxic death which occurred 2 months after high dose melphalan due to a combination of infection and possible anthracycline...
The application of high-dose melphalan and autologous stem cell transplant (SCT) to systemic AL amyloidosis (AL) has evolved over the past two decades and remains an important component of therapy for patients with AL. The era of novel agents created the opportunity to provide well -tolerated ...