To gain insight into the adaptive immune response, we conducted an analysis of antigen-specific CD8 + T cells before and after the administration of the high-dose seasonal influenza vaccine (Fluzone) over six seasons (2014, 2018, 2019, 2021, 2022, and 2023) in a cohort of healthy older ...
npj Vaccines volume 8, Article number: 12 (2023) Cite this article 3987 Accesses 3 Citations 2 Altmetric Metrics details Abstract Influenza B virus (IBV) strains are one of the components of seasonal influenza vaccines in both trivalent and quadrivalent formulations. The vast majority of these ...
The adjuvanted recombinant H7 vaccines were well-tolerated regardless of antigen dose (Fig. 2 and Table 2), and there was no evidence of increased frequencies of subjects experiencing adverse events (AEs) with increasing dose. In general, the frequencies and distribution of local and systemic AEs...
HD, High-dose intramuscular vaccine (60 μg HA/strain); ID, intradermal vaccine; GMT, geometric mean titer. a Post-vaccination GMT ratio. GMT values and the number of subjects used to determine each value are listed in Table 2. 3.5. Safety and reactogenicity For all vaccines, most ...
Vaxxas, a clinical-stage biotechnology company commercializing a novel vaccination platform, today announced the initiation of a Phase I clinical trial with the first needle-free inactivated seasonal influenza vac...
A strategy of a more intense vaccination included comparisons between standard-dose intramuscular vaccines with either a higher dose or higher concentration of intramuscular vaccine, a booster of standard vaccine among poor seroresponders, experimental virosomal vaccine with higher antigenicity, or ...
Vaccination is one of the most cost-effective ways to prevent infection. Influenza vaccines propagated in cultured cells are approved for use in humans, but their yields are often suboptimal. Here, we screened A/Puerto Rico/8/34 (PR8) virus mutant libraries to develop vaccine backbones (define...
We thank Flu Lab (grant to K.L.M.) and the University of Pennsylvania’s Behavior Change for Good Initiative and Center for Health Incentives and Behavioral Economics for their financial support of the sweepstakes and its evaluation. The Flu Lab had no role in study design, data collection ...
b Dose-response curves of HNC-1664 for the inhibition of infection (solid black line) and cell viability (dashed blue line) in Vero E6 cells (n = 3). c Representative IFA images showing the SARS-CoV-2 WT strain NP protein (green) and nuclei (blue) in Caco-2 cells (n = ...
Vaccines for illnesses such as whooping cough, influenza and chickenpox7 HSA Eligibility As noted already, the other major advantage of having an HDHP, besides typically lower premiums, is that it allows you to contribute to a health savings account. Because HSA contributions come from pre-tax...