Adjuvanted (aIIV) and high-dose (HD-IIV) inactivated influenza vaccines were similarly effective against influenza in several studies based on diagnostic codes. However, less is known about their relative vaccine effectiveness (rVE) against laboratory-confirmed influenza and they have never been ...
Currently in the U.S., two influenza vaccines are licensed exclusively for use in seniors: an egg-grown trivalent inactivated high dose (HD-IIV3) influenza vaccine (Fluzone® High-Dose, Sanofi Pasteur) and an egg-grown trivalent inactivated adjuvanted (aIIV3) influenza vaccine (Fluad®, ...
Falsey AR, Treanor JJ, Tornieporth N, Capellan J, Gorse GJ. Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older.J Infect Dis. 2009;200:172–80. doi:10.1086/599790. PMID: 19508...
Economic evaluation of MF59 adjuvanted vaccine against influenza in the high-risk elderly population in France - Piercy, Ryan, et al. () Citation Context ...vaccine are based on improvement in immunogenicity which results in this flu vaccine being highly cost effective and vaccination has shown ...
Subjects received two doses of monovalent recombinant influenza H7 vaccine derived from A/GD/2016 at three antigen dose levels (3.75, 7.5, and 15 µg) adjuvanted with AS03 or MF59 administered 28 days apart. The mean subject age was 35.9 years (range: 18–49 years), 55.2% female (...
Most approaches did not find a way to improve this response: an adjuvanted IIV was not more immunogenic than a non-adjuvanted vaccine after allogeneic HSCT;73 the benefit of two doses versus one dose was suggested both for seasonal72 and H1N1 vaccines,77–79,82 but not found in a ...
Current influenza vaccines have a suboptimal effectiveness. The introduction of a novel A/H1N1 influenza virus in 2009 (H1N1pdm09) provided a unique opportunity to study the humoral response to the AS03-adjuvanted H1N1pdm09 vaccine and repeated annual va
This trial also represents the first time Vaxxas will evaluate the response to an adjuvanted vaccine formulation delivered with its HD-MAP technology. Adjuvants are typically used in pandemic vaccines to boost the immune response of participants who have never encountered the targeted virus before. ...
991. Randomized Trial of High Dose, Adjuvanted, and Standard Inactivated Influenza Vaccine Immune Response Against Egg- and Cell-Propagated Vaccine Strains in Older Adults, 2016–2017 SeasonHuong McLean, PhD, MPHMin Levine, PhDJennifer King, MPH...
influenzaolder adultsvaccine effectivenessBACKGROUND. This study estimated the relative vaccine effectiveness (rVE) of the MF59-adjuvanted trivalent influenza vaccine (aTIV) versus high-dose trivalent inactivated influenza vaccine (HD-TIV) for prevention of influenza-related medical encounters (IRMEs) ...