The most common (>10%) adverse reactions, including laboratory abnormalities (>15%), were glucose increased (38%), instillation site discharge (33%), triglycerides increased (30%), fatigue (24%), bladder spasm (20%), micturition (urination urgency) (19%...
High dose diuretics have been associated with modest creatinine changes without true renal injury. We hypothesized that compared to usual care, ultra-high dose diuretics would be safe and effective in critically ill patients with decompensated heart failure. Aim To explore the safety of ultra-high ...
Because serum creatinine is used to estimate eGFRcrea, associated genetic loci may be relevant to creatinine production or metabolism rather than kidney function per se. For this reason, we contrasted associations of eGFRcrea versus eGFRcys, the latter estimated from an alternative and creatinine-...
In order to understand the influence and characteristics of clinical factors on the survival of DHMM/non-DHMM, univariate Cox regression analysis was further performed on the two subgroups. As shown in Fig.2A, for non-DHMM, age, ECOG PS, hemoglobin, albumin, creatinine, β2-MG, LDH, percent...
a,b, Peak levels of CAR T cells reached in the blood (a) and AUC0–28(b).c, Peak CAR T-cell levels by tumor burden quartile, as determined by SPD of target lesions. For all box plots, the center line denotes the median, box limits the upper and lower quartiles and whiskers 1.5...
In unadjusted and case-mix adjusted models, lower values of albumin, creatinine, protein intake, hemoglobin, and dialysis dose and a higher erythropoietin dose were associated with a higher platelet count. Compared with patients with a platelet count of between 150 and 200 × 103/μL (reference...
ascorbic acid, have an Eastern Cooperative Oncology Group (ECOG) performance status of 0–2, a life expectancy of ≥3 months, normal glucose-6-phosphate dehydrogenase (G6PD) activity, normal renal function (serum creatinine of <1.2 mg/dl), no evidence of oxalosis by urinalysis, no evidence ...
(PS) ≤2; a life expectancy ≥12 weeks; and adequate bone marrow function (neutrophil count ≥2000/mm3, platelet count ≥100 000/mm3, hemoglobin≥10 g/dl), renal function (serum creatinine ≤125 µmol/l) and liver function [bilirubin level ≤1.25 × upper normal limit (ULN), serum ...
Table 2:TCN2 genotype effects on abnormal levels of HCY, MMA, creatinine and B12 at the study start among those who developed dementia. Note that a cluster of four factors: raised homocysteine, raised methylmalonic acid, high creatinine, plus TCN2 766G homozygosity occurs at the study start ...
Creatinine clearance was normal in most patients who weighed C 100 to \ 120 or C 120 kg. The clin- ical presentation of VTE did not differ by body weight group; however, patients weighing C 100 to \ 120 or C 120 kg were more likely to have had a previous VTE than those in lower ...