Limitations to MPRAs include a lack of endogenous chromatin context, and a loss of relevant epigenetic modifications. As MPRAs are typically used in homogenous cell populations, this restricts their application in rare cell types or cells that are challenging to maintain in culture. However, recent...
we identified CST6 as a gene frequently silenced by aberrant promoter hypermethylation in estab- lished glioma cell lines and a small group of primary un- cultured adult brain tumors.10 Although much work has been done analyzing cystatin E/M expression and function in the context of breast canc...
That was an Outside Context Problem; so was the suitably up-teched version that happened to whole planetary civilisations when somebody like the Affront chanced upon them first rather than, say, the Culture. The Culture had had lots of minor OCPs, problems that could have proved to be termi...
This paper presents the findings of a multi-year mixed method study of source country perspectives on the causes, consequences, and policy responses to the migration of HRH with specific reference to the Philippine context. It addresses one of four countries that participated in the larger study,...
falciparum in the Peruvian Amazon context, particularly points of exposure, with relevance and potential generalizability to other low-transmission contexts. Therefore, future analytical approaches ought to focus on locations and populations at high-risk of Plasmodium species-specific infections where such ...
The remainder of the road to the Reno–Benteen defense site was graveled. The construction drawings show that significant cuts and fill were made along the right-of-way. Archival research relative to the construction of the road along battle ridge and from Custer battle- field to the Reno–...
They may, however, have also been transferred from everyday lan-guage into the legal language without having acquired a specific legal meaning until used in the context of a legal text. This transfer process did not cause the creation of whole lexical inventories within the Leges tradition, but...
While we did not observe a population of CCR9+ cells in our lung donors, we cannot exclude the possibility of CCR9 expression in lung or other non-gut tissue in the context of inflammation or disease. CCR4, often thought to mediate homing primarily to skin and lung (Griffith et al., ...
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Future investigations might lead to unraveling the huge potential of ILK as a therapeutic target by taking these repurposed drugs along with reported inhibitors like QLT-0267 and OSU-T315 in the context of high-grade meningioma. An earlier investigation with QLT-0267 in glioblastoma xenograft models...