This phase 2, single-arm, open-label, registrational ZUMA-12 trial (Clinicaltrials.gov no.NCT03761056) was conducted at seven medical centers in the United States, Australia and France (Extended Data Table1). The study protocol and statistical analysis plan are included in theSupplementary Inform...
Safety laboratory studies included measurement of transaminase, bilirubin, and creatine kinase levels. Adjudicated cardiovascular events included cardiovascular death, myocardial infarction, hospitalization for unstable angina, coronary revascularization, stroke, and hospitalization for heart failure. Neurocognitive ...
2011. Invited health professionals representing paediatrics, psychology, nursing, occupational therapy, and physiotherapy, as well as parents of high-risk children attended the workshop. The workshop panel included participants from across Australia and New Zealand, as well as an eminent researcher from...
2011. Invited health professionals representing paediatrics, psychology, nursing, occupational therapy, and physiotherapy, as well as parents of high-risk children attended the workshop. The workshop panel included participants from across Australia and New Zealand, as well as an eminent researcher from...
These data were obtained by linear sweep voltammetry for a biscrolled cathode yarn that contains bilirubin oxidase (BOD) as the enzyme. The error bars show the s.d. of maximum areal current density for three cases. Performance of complete BFC in synthetic electrolyte. A complete BFC having ...
Total bilirubin, µmol/L 17.30 ± 13.52 17.80 ± 10.83 .6721 Total cholesterol, mmol/L 4.40 ± 1.10 4.10 ± 1.07 .0024 NT-proBNP at screening, ng/L 6309.3 (5846.7–6808.4) 6015.8 (5643.5–6412.6) .3443 NT-proBNP, ng/L 3653.6 (3360.3–3972.6) 2996.6 (2795.8–3211.8) .0003 Oral heart...
(absolute neutrophil count <1.0 × 109/l, platelet count <75 × 109/l, aspartate aminotransferase and alanine aminotransferase >2.5 × the upper limit of normal, and total bilirubin >1.5 × the upper limit of normal), and primary systemic AL (immunoglobulin light chain) ...
Hypoalbuminemia following abdominal surgery leads to high serum unbound bilirubin concentrations in newborns soon after birth. Background: The serum concentration of unbound bilirubin (UB), which is bilirubin not bound to albumin (Alb), is a better index than total bilirubin concen... A Miwa,I ...
Basic and applied features of multicopper oxidases, CueO, bilirubin oxidase, and laccase. Chem Rec 7, 220–229 (2007). 16. Axelsen, K. B. & Palmgren, M. G. Evolution of substrate specificities in the P-type ATPase superfamily. J Mol Evol 46, 84–101 (1998). 17. Lichtarge, O.,...
Both biliverdin and bilirubin have anti-obesity and anti-glycaemic effects40, while increased Hmox-1 levels ameliorate fatty liver development through recruitment of FGF2141. Hmox-1 can also inhibit pre-adipocyte proliferation and differentiation via activation of Akt42 and FGF21 has been ...