The randomized phase 3 CHART trial (NCT03520478) revealed that rezvilutamide (REZ) plus androgen deprivation therapy (ADT) in high-volume, metastatic, hormone-sensitive prostate cancer (mHSPC) significantly enhanced radiographic progression-free and overall survival than bicalutamide (BIC)-ADT. Accordin...
Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, Davignon J, Erbel R, Fruchart JC, Tardif JC, etal: Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA. 2006, 295 (13): 1556-1565. 10.1001/jama.295.13....
(Low-density lipoprotein cholesterol, HDL-C)、谷丙转氨酶(Alanine aminotransferase, ALT)、谷草转氨酶(Aspartate aminotransferase, AST)、尿素氮(Blood urea nitrogen, BUN)、血氨(Blood ammonia, Ba)、酸性磷酸酶(Acid phosphatase, ACP)、碱性磷酸酶(Alkaline phosphatase, ACP)与免疫球蛋白M (ImmunoglobulinM, ...
Furthermore, the oral administration of EGCG to wild-type mice at a daily dosage of 100 μg day−1 g−1 of body weight for 2 months led to a notable decrease in the level of serum alanine transferase and alkaline phosphatase, which were initially elevated due to the consumption of a...
osteoblasts, inhibit the proliferation and differentiation of osteoclasts, and address various bone-related pathologies. The compound has been shown to enhance alkaline phosphatase (ALP) activity, elevate serum osteocalcin (BGP, bone Gla-protein) levels, and increase bone mineral density (BMD) [13]....
Plates were developed by incubation with anti-IFNγ–biotin and streptavidin-alkaline phosphatase according to the manufacturer’s instructions (Mabtech). Spots were developed using the AP Conjugate Substrate kit (Bio-Rad). Spots were counted in an automated ELISpot reader (C.T.L. ImmunoSpot). ...
Alkaline phosphatase, U/L 72.1±3.5 a SD=standard deviation. b Score >4 indicates frailty. c Maximum strength of dominant hand. d Values reported as <0.3 mg/dL were assumed to be 0.3 mg/dL. Strain Recovery and Microbiota Composition Absolute quantification by qPCR of five probiotic strains ...
Blanquart C, Barbier O, Fruchart JC, Staels B, Glineur C. Peroxisome proliferator-activated receptor alpha (PPARalpha ) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes. J Biol Chem. 2002;277:37254–9. Article CAS PubMed Google Sch...
ALK alkaline phosphatase, AST aspartate aminotransferase, TBN total bilirubin, ALT alanine aminotransferase, Ca calcium, BUN urea nitrogen, UA uric acid, Cr creatinine, CHOL total cholesterol, TG triglycerides, HDL.c high-density lipoprotein, LDL.c low-density lipoprotein. HBA1c glycated hemoglobin, ...
During osteogenic differentiation, the MC3T3-HSD1 cells exhibited decreased alkaline phosphatase (ALP) activity at 7 days after osteogenic induction and alizarin red-stained (ARS) calcium deposits at 14 and 21 days after osteogenic induction, respectively (Fig. 3a). Consistently, the mRNA expressions...