High-dose methotrexate (HDMTX) therapy is an important component in treatment regimens for acute lymphoblastic leukemia (ALL). Courses are associated with a risk of renal injury, delayed elimination, and increased systemic toxicity. Recently hypoalbuminemia has been recognized as yet another risk ...
In this sample, most children had retinol intakes above the Tolerable Upper Intake Level (UL) and liver VA concentrations above the proposed cutoff for “hypervitaminosis A” (>1 µmol/g liver). There was no evidence of chronic VA toxicity, suggesting that the liver VA cutoff value should...
In contrast, steroid resistance is believed to be associated with a high risk of developing chronic renal failure. Recent reports suggest that the histologic pattern of NS in children may be changing, but whether the change is accompanied by a parallel change in steroid sensitivity is unknown. ...
It is transported to the liver tightly bound to albumin (unconjugated bilirubin) and metabolized by conjugation with glucuronic acid molecules via bilirubin UDP-glucuronosyltransferase to be excreted with the bile (conjugated bilirubin). Bilirubin is a reddish-yellow bile pigment whose presence in ...
High bilirubin levels might be a symptom of liver disease in adults or older children, but it can be common in newborns. Bilirubin is a naturally occurring organic molecule that appears in bile, blood, urine and body fluids as a result of the breakdown of red blood cells. It is classified...
Pediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from molecular biology to epidemiology. Use of model organisms and in vitro techniques relevant to developmental biology and medicine are ...
1. Plasma total cholesterol, high-density-lipoprotein (HDL)-cholesterol total protein, albumin and globulin levels were estimated in blood samples from thirty children with kwashiorkor, thirty-five with marasmus, twenty-eight with marasmic-kwashiorkor and twenty-seven control children.2. HDL-cholesterol...
Data S1. 71 NbHSA sequences, the pI, hydrophobicity, and the number of cysteine residues of NbHSA CDR3s, and the ELISA affinities of NbHSA towards different albumin species. Related to Figure 1 and Methods Data S2. SPR kinetic analysis, thermostability, and pharmacokinetic analysis of 20 dif...
Abbreviations: HSA, human serum albuminIEL, intraepithelial lymphocyteLT, leukotrieneTNP, trinitrophenylICAM-1, intercellular adhesion molecule-1Pediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from...
Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular disease (CVD) risk in children. Non-high density lipoprotein-cholesterol (non-HDL-C) has been shown to be a good predictor of cardiovascular events. Recent data in adul