Low- and High-AffinityCassio, FernandaLeao, Cecilia
Then, nicotinic receptors provided an example of complex ultrarapid reactions: fast activation at a low ligand affinity, then desensitization if the ligand is not rapidly removed. Here, we describe synaptic transmission as a chain of low-affinity rapid reactions, assisted by many slower regulatory ...
The theory of passive uptake and low branchial permeability has been used as an explanation for the potentially low affinity of nitrate to cause toxicity compared to other nitrogenous wastes (Camargo et al., 2005). Stormer et al. (1996) suggested that nitrate ions within the blood plasma of ...
High and low affinity carbohydrate ligands revealed for murine SIGN-R1 by carbohydrate array and cell binding approaches, and differing specificities for SIGN... Christine,Galustian,Chae,... - 《International Immunology》 被引量: 173发表: 2004年 Phage-display library selection of high-affinity human...
The V2 tail was originally added given its high affinity for β-arrestin2 and for its ability to stabilize the interaction between a given receptor and the recruited arrestin; this addition is indispensable for those of low-affinity or for transient β-arrestin recruitment at many GPCRs. The ...
(Fig.4eand Supplementary Fig.3c). Human OXTR is activated and binds to its natural ligand OXT with high affinity or to arginine vasopressin (AVP) with low affinity20. To investigate the role of OXT/AVP ligand signaling in facilitating the invasive capacity of OXTRHighCAFs, the OXT/AVP ...
High Context vs low context Hight-ContextandLow-Context Hight-Context Ahight-contextcommunicationormessageisoneoftheinformationiseitherinthecontextorinternalizedintheperson,whileverylittleisinthecoded,explicit,transmittedpartofthemessage.Low-context Low-contextcommunicationisjusttheopposite,themassoftheinformationis...
Glucocorticoid up-regulation of high-affinity interleukin 6 receptors on human epithelial cells. Proc Natl Acad Sci U S A. 1990;87:2838–42. Article CAS PubMed PubMed Central Google Scholar Goswami R, Lacson R, Yang E, Sam R, Unterman T. Functional analysis of glucocorticoid and insulin...
However, the low affinity of S-CIT to S2 relative to S1 hampers the possibility to reveal the specific therapeutic potentials in targeting this site. Thus, a high affinity and selective S2-bound ligand would facilitate not only a thorough mechanistic understanding of allosteric communications between...
In preparing for the use of this assay for HTS, we found that CarD requires DNA to be present for high affinity interaction RNAP (12 nM vs 2 µM without DNA at 37 °C, Fig. 3). This binding affinity is consistent with the binding affinity predicted from rate constants determined ...