VHL and HIF-1 : gene variation and prognosis in early-stage clear cell renal cell carcinoma[J]. Med Oncol, 2014, 31(3): 840. DOI: 10. 1007/s12032-014-0840-8.Lessi F,Mazzanti C M,Tomei S,et al.VHL and HIF-1alpha:gene variations and prognosis in earlystage clear cell renal ...
Hypoxia-inducible factor 1 alpha (HIF-1伪) is involved in transcription of hypoxia-inducible genes. In normoxia, it binds von Hippel-Lindau (VHL) resulting in ubiquitin-proteasome degradation. This requires hydroxylation at prolines 564 (P564) or 402 (P402) within the oxygen-dependent ...
HIF-1alpha plays a key role in endothelial cell hypoxic responses by regulating hypoxia-induced endothelial autocrine VEGF.;pVHL has been shown to be important in placental vasculogenesis during development. In the third chapter of this dissertation, I investigated the role of pVHL during vessel ...
Reports that hypoxia-inducible factor-1-alpha (HIF-1a) binding to von Hippel-Lindau tumor repressor protein (VHL) is regulated by stimulus-sensitive proline hydroxylation. Ability of VHL to recognize HIF-1a under normoxic conditions; Results indicating that proline hydroxylation is the primary ...
Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC & Conaway JW (2000) Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci USA 97, 10430-10435.Kamura, T., Sato, S., Iwai, K., Czyzyk-Krzeska, M.,...
HIF-1α and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases. Oncogene. 2007; 26 :604–9. [ PubMed ]Paltoglou S, Roberts BJ. HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour ...
Under-expression of VHL and over-expression of HDAC-1, HIF-1alpha, LL-37, and IAP-2 in a ected skin biopsies of pa- tients with psoriasis. Int J Dermatol 2007; 46:239-246.Tovar LE, Cancino JC, Garsia VF, et al. Underexpression of VHL and over-expression of HDAC-1 ,HIF-1 ...
The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activityHIF-1
The prevention of the interaction between E3 ligase VHL and HIFp-1 alpha may improve tolerance to hypoxia and ameliorate the prognosis of many diseases. To obtain novel potent inhibitors of VHL/HIF-1 alpha interaction, a series of hydroxyprolinep-based inhibitors were investigated for structural ...
HIF1 alphaKaplan-Meier survival analysisBladder carcinomaPurpose Our study was aimed to understand the importance of LIMD1-VHL-HIF1 alpha pathway in development of bladder carcinoma (BlCa) in association with arsenic prevalence.Basu, MuktaSSKMChatterjee, Amvrin...