Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. In neuroblastoma specimens, HIF-2α but not HIF-1α is strongly expressed in well-vascularized areas. In vitro, HIF-2α protein was ...
Overexpression of hypoxia-inducible factors (HIF), HIF-1alpha and HIF-2alpha, leads to the up-regulation of genes involved in proliferation, angiogenesis, and glucose metabolism and is associated with tumor progression in several cancers. However, the contribution of HIF-1alpha versus HIF-2alpha ...
manganese-mediated expression and activity of HIF-1alpha protein were largely blocked by treatment with the inhibitor of p38 MAPK (SB203580), JNK-1/2 (SP600125), or ERK-1/2 (PD98059), suggesting roles of these MAPKs in the manganese-induced HIF-1alpha protein expression and activity. Mor...
2-Methoxyestradiol enhances radiosensitivity in radioresistant melanoma MDA-MB-435R cells by regulating glycolysis via HIF-1α/PDK1 axis H. Zhao et al., "2-Methoxyestradiol enhances radiosensitivity in radio- resistant melanoma MDA-MB-435R cells by regulating glycolysis via HIF-1α∕PDK1 ... ...
Neuroprotection by Orexin-A via HIF-1α induction in a cellular model of Parkinson's disease Neuroprotection by Orexin-A via HIF-1alpha induction in a cellular model of Parkinson's disease. Neurosci Lett 2014; 579: 35-40... Y Feng,T Liu,XQ Li,... - 《Neuroscience Letters》 被引量:...