Human Herpes Virus 6 (HHV-6) brain infection presenting with manic-depressive symptomsHuman Herpes Virus, subtype 6 (HHV-6) has been implicated in several neuropsy-chiatric conditions, such as multiple sclerosis, delirium and dementia. We present a case of a young woman with no psychiatric ...
Our study hints to a unique stage in viral life cycle, which is not yet being understood completely. PCR-based DNA studies would not identify this stage in viral life cycle as a clinically important stage in virus activation. However, molecular impact of this stage of HHV-6 on host cell s...
In infants with signs and symptoms of classic roseola infantum, human herpesvirus 6 (HHV-6) can be the causative agent. However, since this diagnosis has various differential diagnoses, other causes for fever and rash should be excluded. In immunocompetent adults with symptomatic HHV-6 disease,...
Use of valganciclovir in patients with elevated antibody titers against Human Herpesvirus-6 (HHV-6) and Epstein—Barr Virus (EBV) who were experiencing cen... Background Twelve patients with long-standing symptoms of central nervous system (CNS) dysfunction were found to have elevated antibody titr...
HHV-6 encephalitis appears to be a major and potentially fatal complication of allogeneic HSCT. AMS appears to be the most common initial presentation. This symptom occurred in our cohort of patients within 1–3 months of transplantation. Other common clinical symptoms/signs included seizures, headac...
When PCR analysis was performed on the MS brains and control brains, however, HHV-6 DNA was found to be comparable in both groups; this was thought to be evidence that HHV-6 is a commensal virus of the brain. Immunocytochemistry directed against HHV-6 proteins was also performed and ...
Indeed, in a unique study using a HCT mouse model infected with murine roseolovirus (a homolog of HHV-6), investigators demonstrated viral reactivation in the lung that induced an IPS-like phenotype48. These findings are concordant with a study demonstrating HHV-6 as the most frequently ...
Moreover, in PPR we found a persistent reactivation of HHV-6 and/or HHV-7 with higher viral loads than in typical PR, accounting for the unusual persistence of the illness, the more frequent and severer systemic symptoms and the oral lesions. In conclusion, we describe an unusual persistent...
Anti-IL6 antibody has been useful in alleviating symptoms due to IL-6 overproduction (one of the HHV-8 genes encodes a viral variant of this cytokine). A case series showed that the initiation of ART did not prevent relapse of disease, but may prolong survival. ...
HHV-6 has two viral subspecies, HHV-6A and HHV-6B. HHV-6B is known as the causal virus of exanthema subitum in childhood, whereas specific diseases associated with HHV-6A have yet to be identified [4], [5]. After primary invasion, HHV-6B persistently infects leukocytes of the host, ...