为探讨环孢菌素A(CSA)联合霉酚酸酯(MMF)方案对主要组织相容性抗原(H-2)半相合小鼠非清髓骨髓移植后急性移植物抗宿主病(aGVHD)的预防作用,建立了H-2半相合纯种近交系小鼠[供鼠为C57BL/6J,受鼠为C57BL/6J×BALB/C杂交F1代小鼠]的非清髓骨髓移植模型,采用CSA+MMF或CSA+MTX作为aGVHD预防方案,观察50天,记录...
GVHD的主要特征是移植物对宿主的免疫反应,导致多个器官和组织的损害。舌头上的白斑是GVHD的常见表现之一,称为口腔GVHD。这种情况可能会引起患者的不适,包括口干、味觉改变、吞咽困难和疼痛等症状。 治疗口腔GVHD的主要方法是使用免疫抑制剂来控制免疫系统的过度反应。糖皮质激素是最常用的药物,可以有效地减轻炎症和症状。
Role of T cell subsets in lethal graft-versus- host disease (GVHD) directed to class I versus class II H-2 differences I. L3T4+ cells can either ... Sprent,J. - 《Journal of Experimental Medicine》 被引量: 484发表: 1988年 Role of T cell subsets in lethal graft-versus-host disease...
Detailed information was sought on the capacity of purified Lyt-2+ cells to mediate lethal graft-versus-host disease (GVHD) directed to class I H-2 differences. When B6 Lyt-2+ cells were transferred to irradiated class I-different (B6 x bm 1)F1 mice, three different patterns of lethal GV...
It is currently thought that acute GVHD cannot be elicited in the absence of Ag presentation by radiosensitive host hematopoietic-derived APCs after allogeneic BM transplantation. Because clinical data suggest that sex-mismatched H-Y Ags may be important minor histocompatibility Ags for GVH responses,...
An 18-year-old female (patient 1) who underwent BMT from an HLA-identical sibling for ALL in first CR, developed generalized erythema and profuse watery diarrhea, which progressed to acute GVHD of grade III severity, resistant to steroid control. After continuous 24-h administration of FK506,...
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area, you can drink mellow Qiandao Lake wine, taste authentic Chun 'an flavor food, enjoy the beautiful scenery of the lake and mountain; Looking at the lake shoreline, the Asian Games venue - Qiandao Lake Huamei resort is leading the development of “cycling events + ecological research + ...
科技日报讯 (记者雍黎 通讯员曾理)1月28日,记者从陆军军医大学新桥医院获悉,该院血液病医学中心主任张曦团队阐释了间充质干细胞(MSCs)综合预防移植物抗宿主病(GVHD)的优化输注方法,进一步优化了造血干细胞治疗中GVHD的综合预防效果。研究成果日前在国际学术期刊《肿瘤学纪要》刊发。
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