Skin wound healing is a critical and complex biological process after trauma. This process is activated by signaling pathways of both epithelial and nonepithelial cells, which release a myriad of different cytokines and growth factors. Hepatocyte growth factor (HGF) is a cytokine known to play mult...
Effects of HGF overexpression and interference on antler MSCs migration. A wound healing test was used to examine the effects of overexpression and interference with HGF on the migration of antler MSCs (Fig. 3A; Supplementary Figure 3). The cell healing ability of the Lenti-HGF group...
in adult organ regeneration and in wound healing.HGF can regulate cell growth,cell motility,and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor.HGF also serves as a paracrine mediator to control placental development and growth.HGF ...
Effects of HGF overexpression and interference on antler MSCs migration. A wound healing test was used to examine the effects of overexpression and interference with HGF on the migration of antler MSCs (Fig. 3A; Supplementary Figure 3). The cell healing ability of the Lenti-HGF group...
through complex downstream signaling sequences. Furthermore, it is crucial for embryo development, organ formation, tissue regeneration, wound healing, and tissue repair [6]. The disruption of the HGF/c-MET signaling pathway, which has been preserved through evolution, leads to a complex array of...
Burnwound;Ad—HGF;Umbilicalcordbloodstemcell;Healing 烧伤创面的修复常采用自体皮肤移植,但大面 积烧伤患者常存在 自体皮肤不足。近十余 年来 ,组 织工程学的发展为大面积皮肤缺损修复开辟 了新途 径。脐血干细胞是一类与骨髓干细胞相 同的具有多 向分化潜能的原始祖细胞 ,有特殊 的生物学特性 ,表 ...
Heparin-binding epidermal growth factor (HB-EGF), part of the EGF family of growth factors, is a mitogenic and chemotactic glycoprotein. HB-EGF is essential for normal cardiac valve formation and heart function as well as cutaneous wound healing. Research suggests that HB-EGF plays a critical ...
Wound healing and Transwell assays were performed to determine cell migration and invasion capacities. Epithelial-mesenchymal transi‑ tion (EMT)-related marker expression levels were also examined. Subcutaneous implantation and tail vein injection models were applied for in vivo growth and metastasis ...
be found in association with the pathologic changes which occur in Alzheimer's disease (Fenton H, et al.,Brain Res. 779(1-2): 262-270, 1998). Furthermore, it has been found that HGF is definitely involved in enhancing cutaneous wound healing processes, including re-epithelialization, neovasc...
The HGF-Met signaling pathway plays a role in liver regeneration, wound healing, neural regeneration, angiogenesis and malignancies. See, e.g., Cao et al. (2001) PROC. NATL. ACAD. SCI. USA 98: 7443-7448, Burgess et al. (2006) CANCER RES. 66: 1721-1729, and U.S. Pat. Nos. 5,...