转铁蛋白受体1(Transferrin receptor 1, TfR1)在细胞铁摄取中起到了关键作用,肝细胞TfR1通过与血色病蛋白HFE相互作用,调节铁调素的生成并影响全身铁稳态。在本研究中,我们构建了肝细胞Tfrc敲除小鼠(Tfrcfl/fl; Alb-Cre+),单独敲除...
HFE蛋白的“钩子”部分就像一个钥匙,它会跟体内另一种叫做转铁蛋白受体(TFR1)的蛋白结合。而这个受体,就像是个门锁,HFE蛋白就是那个钥匙。一旦HFE锁住了受体,铁的吸收就会变得更精确,铁不会胡乱地进到体内。说白了,这个蛋白的作用就是保证铁的“运输”不出错。 但是,这个蛋白也不是永远都靠谱。想象一下,如果...
Transferrin receptor 1 (TfR1) performs a critical role in cellular iron uptake. Hepatocyte TfR1 is also proposed to influence systemic iron homeostasis by interacting with the hemochromatosis protein HFE to regulate hepcidin production. Here, we generated hepatocyte Tfrc knockout mice ( Tfrc fl/fl ...
1/2分子的HFE蛋白.蛋白的相对配向表明Tilt和 HFE蛋白限定在相同的细胞膜时发生相互作用,而 不像T细胞受体与MHC—I类蛋白在两个细胞相对 的细胞膜上相互作用.每个HFE蛋白与细胞膜平行 并与1个TfR单体的一侧螯合,而TfR同型二聚体仍 竖立在细胞膜上.HFE与Tilt之间界面很宽,总计 ...
专利权项:1.一种重组HFEB2M融合蛋白,其特征在于,所述融合蛋白能在体外与TfR结合,所述融合蛋白包含信号肽、HFE蛋白、间隔区、B2M蛋白和His标签,所述融合蛋白的氨基酸残基序列为SEQIDNO.6或SEQIDNO.7,其中所述TfR为TfR1,且所述融合蛋白在pH7.5的环境下结合TfR1。
The iron responsive element/iron regulatory protein system (IRE/IRP) regulates TFR1 and ferritin expression, adapting iron entry into the cell (TFR1) and the capacity of iron storage in cells (ferritin), to the variations of cellular iron content [50,53]. The second hit (Figure 1) ...
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综上所述,HFE 与细胞铁的摄取密切相关,且 通过与转铁蛋白 竞争性结合 TfR1 , 从而降低细胞铁水平的摄取 。 如表达异常, 细胞铁摄取增多, 可能与肿瘤的发生有关。 文献报道, 抗转铁蛋白受体单克隆抗体(TfR mAb ) 或其单链抗体 能特异识别肿瘤细
2 The mutation disrupts a critical disulfide bond in the α3 domain of HFE protein and abrogates binding of the mutant HFE protein to B2m, leading to impaired HFE protein intracellular trafficking, incorporation into the cell membrane, and association with TfR1.3 Studies in mice with targeted ...
HFE also interacts with TfR2 via domains that differ from those involved in HFE/TfR1 interaction [16], [17]. TfR2 is a relative of TfR1 that is predominantly expressed in hepatocytes and erythroid precursors [18]. TfR2 binds to Fe2-Tf with low affinity [19], and unlike TfR1, it ...