However, if given the choice, many patients prefer a DPI over the HFA inhaler. The transition offers an opportunity to review patients’ current treatment and the proficiency of their inhaling technique. Moving to CFC-free inhalers will have revenue implications....
Four (4) placebo-controlled crossover trials were conducted with healthy subjects: (1) a cumulative-dose trial using 42 to 336 mcg of salmeterol CFC inhalation aerosol given alone or as ADVAIR HFA 115 mcg/21 mcg, (2) a single-dose trial using 4 inhalations of ADVAIR HFA 230 mcg/21 mcg...
In the one open label controlled study in 456 COPD patients, the overall incidence of adverse events was also similar between Atrovent HFA and Atrovent CFC formulations. Overall, in the above mentioned studies, 9.3% of the patients taking 42 mcg Atrovent HFA and 8.7% of the patients taking 42...
Escribano A, Tutuncu A, Lohr I, Carlholm M, Polanowski T (2006) Clinical comparability between the CFC and HFA budesonide pressurised metered- dose inhalers in paediatric patients with asthma: a randomised controlled trial. Curr Med Res Opin 22: 1085-1092....
Comparison of the safety of drug delivery via HFA‑ and CFC‑metered dose inhalers in CAO. Eur Respir J 2000;15:663‑9.Huchon G, Hofbauer P, Cannizzaro G, Iacono P, Wald F. Comparison on the safety of drug delivery via HFA- and CFC- metered dose inhalers in CAO. Eur ...
Similarities and Differences Between CFC and HFA Driven Inhalersdoi:10.1089/jam.1997.10.Suppl_1.S-7.
Triamcinolone inhalers with hydrofluoroalkane (HFA) or chlorofluorocarbon (CFC) propellants have similar efficacyAsthma, treatmentTriamcinolone, therapeutic useInpharma Weekly -doi:10.2165/00128413-200012190-00030NoneSpringer International PublishingInpharma Weekly...
Objectives: Chlorofluorocarbon metered-dose inhalers (CFC-MDIs) have been reformulated, and now, the non-ozone-depleting propellant, hydrofluoroalkane, is used in metered-dose inhalers (HFA-MDIs). The aim of the study was to evaluate the bronchodilation response of the 2 products.Methods: ...
Hydrofluoroalkane-134a beclomethasone dipropionate (HFA-BDP) extra-fine aerosol and HFA-fluticasone propionate (HFA-FP) are chlorofluorocarbon-free inhalers. We conducted an 8-week, open study to demonstrate the equivalence of HFA-BDP (800 μ g day−1) and HFA-FP (1000 μ g day−1) ...